Nanofiber-Based Delivery of Therapeutic Peptides to the Brain
Source abstract
Abstract
The delivery of therapeutic peptides and proteins to the central nervous system is the biggest challenge when developing effective neuropharmaceuticals. The central issue is that the blood-brain barrier is impermeable to most molecules. Here we demonstrate the concept of employing an amphiphilic derivative of a peptide to deliver the peptide into the brain. The key to success is that the amphiphilic peptide should by design self-assemble into nanofibers wherein the active peptide epitope is tightly wrapped around the nanofiber core. The nanofiber form appears to protect the amphiphilic peptide from degradation while in the plasma, and the amphiphilic nature of the peptide promotes its transport across the blood-brain barrier. Therapeutic brain levels of the amphiphilic peptide are achieved with this strategy, compared with the absence of detectable peptide in the brain and the consequent lack of a therapeutic response when the underivatized peptide is administered.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: RNA Interference and Gene Delivery · Supramolecular Self-Assembly in Materials · Advanced biosensing and bioanalysis techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
UCL School of Pharmacy, 29−39 Brunswick Square, London WC1N 1AX, United Kingdom
Department of Chemistry and Centre for Scientific Computing, University of Warwick, Coventry CV4 7AL, United Kingdom
Computational Biophysics Laboratory, Institute of Life Sciences Research, University of Bradford, Yorkshire BD7 1DP, United Kingdom
Biophysics Centre, Institute of Structural and Molecular Biology and Department of Biological Sciences, Birkbeck, University of London, London WC1E 7HX, United Kingdom
School of Physics, University of Exeter, Stocker Road, Exeter EX4 4QL, United Kingdom
GlaxoSmithKline, Pharmaceuticals R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, United Kingdom
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