Multistrand RNA Secondary Structure Prediction and Nanostructure Design Including Pseudoknots
Source abstract
Abstract
We are presenting NanoFolder, a method for the prediction of the base pairing of potentially pseudoknotted multistrand RNA nanostructures. We show that the method outperforms several other structure prediction methods when applied to RNA complexes with non-nested base pairs. We extended this secondary structure prediction capability to allow RNA sequence design. Using native PAGE, we experimentally confirm that four in silico designed RNA strands corresponding to a triangular RNA structure form the expected stable complex.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: RNA and protein synthesis mechanisms · RNA modifications and cancer · DNA and Nucleic Acid Chemistry
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Basic Science Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States
Center for Cancer Research Nanobiology Program, NCI-Frederick, Frederick, Maryland, United States
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510, United States
Biomolecular Science and Engineering Program, University of California, Santa Barbara, California 93106-9510, United States
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