DataVXACS NanoPaper
journal article·2025-09-30

A Near-Infrared-II Molecular Probe for Early Diagnosis of Acute Kidney Injury Induced by Diverse Etiologies

Yiqi Zhu, Dingyuan Yan, Jun Zhu, Hongbo Xu, Weijie Zhang, Jianquan Hou, Dong Wang, Ben Zhong Tang

ACS Nano· Volume 19· Issue 38
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Source abstract

Abstract

Acute kidney injury (AKI) is a clinical syndrome characterized by complex etiologies and usually lacks obvious clinical manifestations at the early stage. Compared with traditional imaging methods, optical imaging is broadly considered to be a promising technique for diagnosis of kidney dysfunction own to the merits of noninvasiveness, high sensitivity and fast feedback speed. Herein, we report a renal-clearable fluorophore, PEG-TBSe, for in vivo imaging across diverse AKI models in the second near-infrared (NIR-II, 1000-1700 nm) window. Notably, PEG-TBSe possesses an ultrasmall size (∼5.5 nm) that is suitable for renal clearance, allowing for comprehensive assessment of AKI severity in prerenal, renal and postrenal models. In addition, the real-time imaging capacities of PEG-TBSe are sensitive to early changes in AKI, enabling the noninvasive identification of renal lesions earlier than common clinical assays. Overall, this study demonstrates an effective NIR-II small molecular probe for the early diagnosis and evaluation of the severity of kidney dysfunction in different AKI models.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Acute Kidney Injury Research · Lanthanide and Transition Metal Complexes · Renal and Vascular Pathologies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Urology, The Fourth Affiliated Hospital of Soochow University, Medical Center of Soochow University

Suzhou Dushu Lake Hospital

Center for AIE Research, Guangdong Provincial Key Laboratory of New Energy Materials Service Safety, College of Material Science and Engineering

Shenzhen University

Department of Urology

The First Affiliated Hospital of Soochow University

Guangdong Basic Research Center of Excellence for Aggregate Science, School of Science and Engineering

The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen)

Funding

Basic and Applied Basic Research Foundation of Guangdong Province · Guangdong Provincial Pearl River Talents Program · Science and Technology Planning Project of Shenzen Municipality · National Natural Science Foundation of China · Shenzhen University · Medical-Engineering Interdisciplinary Research Foundation of Shenzhen University · Developmental Fund for Science and Technology of Shenzhen government

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