DataVXACS NanoPaper
journal article·2026-02-24

Neonatal Spinal-Cord-Like Scaffold with Hierarchical Structural and Neurogenetic Microenvironments for Spinal Cord Injury Repair

Baoshuai Bai, Jianhao Wang, Linlin Jiang, Chenbo Zou, Shuo Liu, Zhangyang Qi, Chi Zhang, Zhen Li, Ruizhi Zhang, Yanhan Liu, Gang Lu, Xingqi Song, Chunlin Li, Hua Zhao, Ning Ran, Guangdong Zhou, Xiaohong Kong, Partick Shu Hang Yung, Dong Lei, Shiqing Feng, Hengxing Zhou

ACS Nano· Volume 20· Issue 7
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Source abstract

Abstract

Spinal cord injury (SCI) repair has been a great challenge worldwide because of its complex regeneration mechanisms and limited self-healing. The biomimetic construction of a bioactive scaffold represents a promising direction for SCI repair. Inspired by the efficient self-healing properties of the neonatal spinal cord, this study developed a neonatal spinal-cord-like scaffold (NSLS) aimed at regulating SCI repair at different stages. The NSLS features a neonatal spinal cord matrix, multilevel biomimetic structures, and matching mechanical strength via personalized laser processing and dual-network cross-linking. The microenvironments of the NSLS activate energy metabolism, synaptic formation, and the gliogenesis of neural stem cells (NSCs). Notably, the NSLS could achieve rapid hemostasis and integration with the host spinal cord, facilitating nutrient infiltration and establishing a stable connection in the early stage. Furthermore, NSCs loaded with NSLS (NSLT) promoted nerve repair by promoting microglial M2 polarization to decrease local inflammatory responses in the intermediate stage. Finally, axons grow directionally within the channels and form new connections to enhance neural repair and functional recovery in the late stage. Therefore, NSLT could significantly enhance nerve regeneration and functional recovery after SCI via stage-specific regulation.
Source: openalex_inverted_index · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Nerve injury and regeneration · Neurogenesis and neuroplasticity mechanisms · Spinal Cord Injury Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopaedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopaedics, Advanced Medical Research Institute, and Cheeloo College of Medicine

Shandong University

Department of Plastic and Reconstructive Surgery, Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People’s Hospital

Shanghai Jiao Tong University School of Medicine

Department of Orthopaedics, Tianjin Medical University General Hospital, International Science and Technology Cooperation Base of Spinal Cord Injury

Tianjin Key Laboratory of Spine and Spinal Cord

Department of Geriatric Medicine, Qilu Hospital of Shandong University, Wenhuaxi Road 107, Jinan 250012, China

CUHK−SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences

The Chinese University of Hong Kong

Center for Neuromusculoskeletal Restorative Medicine

Hong Kong Science Park

Department of Orthopaedics, The Second Hospital, Cheeloo College of Medicine

Funding

Taishan Scholar Project of Shandong Province · Shandong University · National Natural Science Foundation of China · Natural Science Foundation of Shandong Province

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