DataVXACS NanoPaper
journal article·2025-12-16

Tuning the Needling Length of Copper Single-Atom Nanozyme for Enhanced Cellular Uptake and Chemodynamic Therapy

Xinyi Shi, Tianwei Song, Yinglong Wu, Xiangyang Li, Xiangfu Meng, Yong Qian, Chenyang Bi, Dongdong Wang, Junchao Qian, Yanli Zhao, Hui Wang

ACS Nano· Volume 19· Issue 49
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Source abstract

Abstract

Single-atom nanozymes (SAEs) with a high catalytic performance have received worldwide attention in tumor therapy. The current SAEs still suffer from a low cell penetration efficiency and tumor accumulation, limiting their therapeutic effect during treatment. Herein, a typical urchin-like carbon-supported copper single-atom nanozyme (UCCSE) is designed for enhanced cascade chemodynamic therapy. The UCCSE is synthesized through a one-step carbonization-reduction strategy using dopamine and copper chloride as precursors. The structure endows UCCSE with enhanced membrane penetration via endocytosis and tumor cell uptake abilities. Upon internalization, the as-prepared UCCSE possesses peroxidase (POD)-mimicking activity for continuous hydroxyl radical (•OH) generation as well as glutathione peroxidase (GPx)-mimicking activity for glutathione depletion. Both cellular and animal experiments exhibit noteworthy needling-length-dependent tumor suppression effects with negligible systemic toxicity. This work provides a simple paradigm for enhanced tumor catalytic therapy through rational regulation of morphology.
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Research context

NanomaterialsCatalysis & surfaces

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

High Magnetic Field Laboratory, Hefei Institutes of Physical Science

Chinese Academy of Sciences

Hefei National Research Center for Physical Sciences at the Microscale

University of Science and Technology of China

Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Hefei Cancer Hospital

Chinese Academy of Science

School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore

Institute of Solid State Physics, Hefei Institutes of Physical Science

Funding

University of Science and Technology of China · National Key Research and Development Program of China · Hefei Institutes of Physical Science, Chinese Academy of Sciences · Hefei Science Center, Chinese Academy of Sciences · National Natural Science Foundation of China · Natural Science Foundation of Anhui Province · High Magnetic Field Laboratory of Anhui Province

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