journal article·2024-03-26Open access

Natural Fat Nanoemulsions for Enhanced Optical Coherence Tomography Neuroimaging and Tumor Imaging in the Second Near-Infrared Window

Xiaorui Geng, Xiao Liang, Yubin Liu, Yuhao Chen, Bin Xue, Xianyuan Wei, Zhen Yuan

ACS Nano· Volume 18· Issue 12

Abstract

High Resolution Image Download MS PowerPoint Slide Optical coherence tomography (OCT) imaging mainly uses backscattered light to visualize the structural and functional information on biological tissues. In particular, OCT angiography can not only map the capillary networks but also capture the blood flow in the tissue microenvironment, making it a good candidate for neuroimaging and tumor imaging in vivo and in real time. To further improve the detection accuracy of cancer or brain disorders, it is essential to develop a natural and nontoxic contrast agent for enhanced OCT imaging in the second near-infrared (NIR-II) window. In this study, a superior biocompatible and highly scattering NIR-II fat nanoemulsion was constructed to improve OCT imaging contrast and depth for monitoring the vascular network changes of the cerebral cortex or tumor. In vivo experimental results demonstrated that a natural fat nanoemulsion can serve as an excellent probe for enhanced OCT neuroimaging and tumor imaging.
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Research context

OpenAlex topics: Optical Coherence Tomography Applications · Photoacoustic and Ultrasonic Imaging · Advanced Fluorescence Microscopy Techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Cancer Center, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR 999078, China

Centre for Cognitive and Brain Sciences, University of Macau, Taipa, Macau SAR 999078, China

Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, China

College of Photonics and Electric Engineering, Fuzhou Normal University, Fuzhou, 350117, China

Shenzhen Key Laboratory of Ultraintense Laser and Advanced Material Technology, Center for Advanced Material Diagnostic Technology, and College of Engineering Physics, Shenzhen Technology University, Shenzhen, 518118, China

Funding

Universidade de Macau · Fundo para o Desenvolvimento das Ci?ncias e da Tecnologia · Natural Science Foundation of Guangdong Province

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