DataVXACS NanoPaper
journal article·2025-06-10

Multifunctional Nanomotors with Aggregation-Induced NIR-II Emission and Photothermal Propulsion for Deep Tumor Penetration and Precise Phototheranostics

Mengli Liu, Haozhe Tan, Bin Bin Chen, Cheng Lu, Bo Wu, Yilin Zhu, Rongyuan Zhang, Zhen Tian, Yumei Luo, Zheng Zhao, Ben Zhong Tang

ACS Nano· Volume 19· Issue 22
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Source abstract

Abstract

The advent of photothermal-driven nanomotors presents exciting opportunities for tumor therapy. However, significant potential remains for improving the permeability of these nanomotors to tumors due to the barrier posed by the tumor stromal microenvironment (TSM). Additionally, advancing their functional integration in photothermal production and second near-infrared (NIR-II) imaging could enable deep-tissue phototheranostics. Herein, we develop multifunctional nanomotors by coating the exquisitely designed aggregation-induced emission (AIE) luminogen onto one hemisphere of the Janus dual-mesoporous silica using a pore-size-selective assembly strategy. Upon laser irradiation, these nanomotors not only emit strong NIR-II fluorescence for tumor diagnosis but also generate effective photothermal heat to induce thermophoresis. Meanwhile, the heat can disrupt tumor stromal structure, thereby reducing the resistance of TSM and facilitating effective propulsion, which improve cellular uptake, transvascular extravasation, and intratumoral penetration. This integrated nanoplatform significantly enhances the efficacy of synergistic active-motion photothermal therapy and chemotherapy, offering a promising strategy for deep tumor penetration and precise phototheranostics.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Micro and Nano Robotics · Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People’s Hospital of Shenzhen

Guangdong Basic Research Center of Excellence for Aggregate Science, School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, Shenzhen Key Laboratory of Functional Aggregate Materials

The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen)

Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 999077, P. R. China

Department of Urology

The First Affiliated Hospital of Soochow University

Funding

National Key Research and Development Program of China · Science, Technology and Innovation Commission of Shenzhen Municipality · National Natural Science Foundation of China · Shenzhen Key Laboratory of Functional Aggregate Materials · Longgang District People?s Hospital of Shenzhen

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