DataVXACS NanoPaper
journal article·2025-08-12Open access

Hybrid Cell Membrane-Functionalized Nanoagents Synergistically Enhance Cuproptosis-Mediated Immunotherapy by Dual Modulation of Glycolytic Metabolism and Tumor Microenvironments

Qiang Li, Meng Dang, Ao He, Xiaoye Li, Meng Ding, Zhuo Dai, Yu Zhang, Weijun Xiu, Siyu Wang, Zhusheng Huang, Yongbin Mou, Lianhui Wang, Heng Dong

ACS Nano· Volume 19· Issue 31
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Source abstract

Abstract

Glycolytic activity of cancer cells not only reduces their vulnerability to cuproptosis but also heightens the immunosuppressive state of the tumor microenvironment (TME). Our study introduces a nanoplatform called dual-remodeling cuproptosis-inducing agent with hybrid cell membrane coating (DREAM), which is crafted to simultaneously modify the metabolic and immunological landscapes of the TME to enhance cuproptosis-driven immunotherapy. This platform exploits cancer-cell-derived membranes for homologous targeting, enhancing tumor specificity, intratumoral penetration, and intracellular copper delivery. DREAM's disruption of glycolysis intensifies the copper overload, triggering cuproptosis in cancer cells. Additionally, it alleviates immunosuppression and bolsters immune responses facilitated by the immunogenic cell death from cuproptosis, further potentiated by the immunostimulatory effect of M1 macrophage membranes. The outcome is a pronounced efficacy in curbing tumor growth and distant metastasis in squamous cell carcinoma and also in suppressing melanoma proliferation and lung metastasis. This research underscores the vital interaction among inhibiting glycolysis, enhancing sensitivity to cuproptosis, and activating immune responses, thereby paving a feasible and integrated pathway in cancer immunotherapy.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Immune cells in cancer · Phagocytosis and Immune Regulation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, 30 Zhongyang Road, Nanjing, Jiangsu 210008, China

Institute for Health Innovation & Technology, Biomedical Engineering Department, National University of Singapore, 21 Lower Kent Ridge Road, Singapore 119276, Singapore

Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L Levy Pl, New York, New York 10029, United States

State Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing, Jiangsu 210023, China

Funding

Natural Science Foundation of Jiangsu Province · National Natural Science Foundation of China · Nanjing Medical Science and Technique Development Foundation · Nanjing Clinical Research Center for Oral Diseases · Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University

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