DataVXACS NanoPaper
journal article·2025-07-01

Defective RuO2 Nanospheres Attenuate Osteoarthritis Progression via Suppressing the ROS/NLRP3/Caspase-1 Signaling Pathway

Jie Lv, Faheem Muhammad, Zheng Wang, Chenfeng Qiao, Xiang Gu, Yuan Liu, Weitong Li, Wenli Gong, Zhongyang Lv, Yuxiang Fei, Liqian Peng, Zhihao Lu, Nuo Xu, Chunqing Hu, Hanwen Zhang, Rui Wu, Xingquan Xu, Hui Wei, Ziying Sun, Dongquan Shi

ACS Nano· Volume 19· Issue 25
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Source abstract

Abstract

Osteoarthritis (OA) is the most prevalent degenerative joint disorder, characterized by chronic inflammation, cartilage degeneration, and the formation of osteophytes, which leads to serious economic and social challenges. Previous studies have demonstrated that oxidative stress-driven inflammation plays a crucial role in the pathophysiological progression of OA. In this study, we presented defective RuO 2 (d-RuO 2 ) as an effective antioxidant for the treatment of OA. Unlike the crystalline RuO 2, the amorphous hydrous RuO 2 nanospheres (composed of self-assembled ultrasmall RuO 2 ) displayed superior nanozymatic antioxidant activities. In vitro studies demonstrated that d-RuO 2 significantly reduced intracellular levels of reactive oxygen species (ROS), and decreased the expression of key inflammatory markers including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX2), tumor necrosis factor- α (TNF- α ), and interleukin-1 β (IL-1 β ), indicating its anti-inflammatory effects. In vivo experiments showed that d-RuO 2 effectively relieved pain, improved physical activity, and mitigated synovitis, cartilage degeneration, and bone remodeling induced by destabilization of the medial meniscus (DMM). Furthermore, the mechanistic investigations indicated that d-RuO 2 attenuated the progression of OA by suppressing the ROS/NLRP3/Caspase-1 signaling pathway. In conclusion, we presented d-RuO 2 as an efficient ROS scavenger, providing a potential therapeutic strategy for OA.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced Nanomaterials in Catalysis · Osteoarthritis Treatment and Mechanisms · Bone and Joint Diseases

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, 321 Zhongshan Road, Nanjing, Jiangsu 210008, PR China

State Key Laboratory of Pharmaceutical Biotechnology

Nanjing University

Branch of National Clinical Research Center for Orthopedics

Sports Medicine and Rehabilitation

Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials

Guangdong Key Laboratory of Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Medical School

Shenzhen University

Department of Orthopedics, Jinling Clinical Medical College

Nanjing University of Chinese Medicine

Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, 321 Zhongshan Road, Nanjing, Jiangsu 210008, PR China

Department of Orthopedics, Nanjing Jinling Hospital, Affiliated Hospital of Medical School

Funding

China National Funds for Distinguished Young Scientists · Six Talent Peaks Project in Jiangsu Province · National Natural Science Foundation of China · Innovation Project of National Orthopedics and Sports Medicine Rehabilitation Clinical Medical Research Center

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