Interfacial Engineering Enhancing Electron Transfer of CaF₂ Nanoparticles for Periodontitis Treatment of Sonotherapy and Bone Resorption

Qiuyu Liu; Yi Wang; Jin Huang; Xiangmei Liu; Congyang Mao; Chaofeng Wang; Yufeng Zheng; Hanpeng Liu; Khin Wee Lai; Zhaoyang Li; Shengli Zhu; Hui Jiang; Zhenduo Cui; Shuilin Wu

doi:10.1021/acsnano.5c01112

journal article·2025-04-08

Interfacial Engineering Enhancing Electron Transfer of CaF₂ Nanoparticles for Periodontitis Treatment of Sonotherapy and Bone Resorption

Qiuyu Liu, Yi Wang, Jin Huang, Xiangmei Liu, Congyang Mao, Chaofeng Wang, Yufeng Zheng, Hanpeng Liu, Khin Wee Lai, Zhaoyang Li, Shengli Zhu, Hui Jiang, Zhenduo Cui, Shuilin Wu

ACS Nano· Volume 19· Issue 13

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Source abstract

Abstract

Conventional periodontitis treatments can be superseded by sonodynamic therapy. In this study, a Zn(OH)F/CaF 2 heterojunction was synthesized via a hydrothermal method, which exhibited good biocompatibility and antibacterial properties. The band gap decreased significantly after the formation of the heterojunction, thereby enhancing the internal electron transfer. In addition, after the bacteria contact with the material, the electrons of the electron transport chain turn to Zn(OH)F/CaF 2 and affect its steady state. Ultimately, H 2 O 2 in an inflammatory environment was used to react with Zn(OH)F/CaF 2 to facilitate electron transfer under the influence of ultrasound, ultimately enhancing the catalytic activity. Zn(OH)F/CaF 2 exhibits significant antibacterial efficacy against Porphyromonas gingivalis and Staphylococcus aureus . Trace elements Ca and Zn can promote tissue repair and osteogenic differentiation, resulting in less bone destruction and intact gingival tissue after periodontitis treatment. This sonodynamic therapy provides a rapid antibacterial, effective, and deep therapeutic method for treating periodontitis.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials Biomaterials Catalysis & surfaces

OpenAlex topics: Bone Tissue Engineering Materials · Bacterial biofilms and quorum sensing · Ultrasound and Cavitation Phenomena

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Materials Science & Engineering, Biomedical Materials Engineering Research Center, Hubei Key Laboratory of Polymer Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, State Key Laboratory of Biocatalysis and Enzyme Engineering

Hubei University

School of Health Science & Biomedical Engineering

Hebei University of Technology

School of Materials Science & Engineering

Peking University

School of Materials Science & Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China

Tianjin University

Department of Biomedical Engineering, Faculty of Engineering

Universiti Malaya

Funding

China National Funds for Distinguished Young Scientists · Natural Science Foundation of Beijing Municipality · National Natural Science Foundation of China · Yanzhao Young Scientist Project · Central Guidance on Local Science and Technology Development Fund of Hebei Province

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