Piercing of the Human Parainfluenza Virus by Nanostructured Surfaces

Samson W. L. Mah; Denver P. Linklater; Vassil Tzanov; Phuc H. Le; Chaitali Dekiwadia; Edwin Mayes; Ranya Simons; Daniel J. Eyckens; Graeme Moad; Soichiro Saita; Saulius Joudkazis; David A. Jans; Vladimir A. Baulin; Natalie A. Borg; Elena P. Ivanova

doi:10.1021/acsnano.3c07099

journal article·2024-01-16Open access

Piercing of the Human Parainfluenza Virus by Nanostructured Surfaces

Samson W. L. Mah, Denver P. Linklater, Vassil Tzanov, Phuc H. Le, Chaitali Dekiwadia, Edwin Mayes, Ranya Simons, Daniel J. Eyckens, Graeme Moad, Soichiro Saita, Saulius Joudkazis, David A. Jans, Vladimir A. Baulin, Natalie A. Borg, Elena P. Ivanova

ACS Nano· Volume 18· Issue 2

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Abstract

This paper presents a comprehensive experimental and theoretical investigation into the antiviral properties of nanostructured surfaces and explains the underlying virucidal mechanism. We used reactive ion etching to fabricate silicon (Si) surfaces featuring an array of sharp nanospikes with an approximate tip diameter of 2 nm and a height of 290 nm. The nanospike surfaces exhibited a 1.5 log reduction in infectivity of human parainfluenza virus type 3 (hPIV-3) after 6 h, a substantially enhanced efficiency, compared to that of smooth Si. Theoretical modeling of the virus-nanospike interactions determined the virucidal action of the nanostructured substrata to be associated with the ability of the sharp nanofeatures to effectively penetrate the viral envelope, resulting in the loss of viral infectivity. Our research highlights the significance of the potential application of nanostructured surfaces in combating the spread of viruses and bacteria. Notably, our study provides valuable insights into the design and optimization of antiviral surfaces with a particular emphasis on the crucial role played by sharp nanofeatures in maximizing their effectiveness.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Antenna Design and Analysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Science, STEM College, RMIT University, Melbourne, Victoria 3000, Australia

CSIRO Manufacturing, Clayton, Victoria 3168, Australia

Department of Biomedical Engineering, Graeme Clarke Institute, The University of Melbourne, Parkville, Victoria 3010, Australia

Departament de Química Física i Inorgànica, Universitat Rovira i Virgili, C/Marcel.lí Domingo s/n, Tarragona 43007, Spain

RMIT Microscopy and Microanalysis Facility, STEM College,RMIT University, Melbourne, Victoria 3000, Australia

The KAITEKI Institute Inc., Chiyoda-ku, Tokyo 100-8251, Japan

Optical Science Centre, Swinburne University of Technology, Hawthorn, Melbourne, Victoria 3122, Australia

Nuclear Signalling Laboratory, Department of Biochemistry and Molecular Biology, Monash University, Monash, Victoria 3800, Australia

School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia

Funding

Ministerio de Ciencia e Innovaci?n · Australian Research Council · Commonwealth Scientific and Industrial Research Organisation · RMIT University · University of Melbourne

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