journal article·2025-08-05

Orchestrating Gut Disorders by Oral Delivery of a Living–Synthetic Hybrid Hydrogel

Kun Zhang, Yi Liang, Qiao Chen, Shirong Zhang, Yanbing Liu, Wei Wu, Li Zhu, Kai Qu, Xian Qin, Yidan Chen, Da Sun, Xu Qiu, Minjun Ye, Jiawei Li, Fei Yan, Chunhui Lang, Lixin Xu, Bo Xiao, Jinyao Liu, Wei Wu

ACS Nano· Volume 19· Issue 30
Publisher page

Abstract

Elevated intestinal inflammation, reactive oxygen species (ROS), and gut microbiota dysbiosis are prominent features of various intestinal disorders. In this work, we develop an oral inulin-based hydrogel delivery system (LICH) containing living probiotics and hyaluronic acid (HA)-modified carbon dot (CD) nanoenzymes to orchestrate gut disorders. Utilizing the hydrophobic properties of HA under acidic conditions, LICH contracts its network to safeguard probiotics during gastric transit. Upon reaching the intestine, HA-modified CD enables spatiotemporal targeting of lesion sites, achieving anti-inflammatory and ROS-scavenging effects. Concurrently, probiotics and inulin synergistically restore a balanced gut microbiota. In a murine model of ulcerative colitis, LICH exhibits prolonged intestinal retention and significantly ameliorates the pathological microenvironment. Transcriptomic and metabolomic analyses further reveal that LICH exerts its therapeutic effects primarily by modulating inflammation, scavenging ROS, and promoting intestinal barrier repair. This study provides a versatile oral platform to regulate multifaceted pathological characteristics for the treatment of intestinal disorders.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Gut microbiota and health · Infant Nutrition and Health · Probiotics and Fermented Foods

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Chongqing University Three Gorges Hospital, Chongqing Municipality Clinical Research Center for Geriatric Diseases, Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College, School of Medicine

Chongqing University

Institute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province

Wenzhou University

Jin Feng Laboratory

Department of Pharmacy Personalized Drug Therapy Key Laboratory of Sichuan Province Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital School of Medicine

University of Electronic Science and Technology of China

State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine Institute of Molecular Medicine Renji Hospital School of Medicine Shanghai Jiao Tong University

Funding

Central University Basic Research Fund of China · National Natural Science Foundation of China · JinFeng Laboratory of Chongqing · Chongqing medical scientific research project · Chongqing Wanzhou Research Project · Fundamental Research Funds for the National Key R&D Project · Science and Technology Research Project of the Chongqing Municipal Education Commission

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