DataVXACS NanoPaper
journal article·2025-07-15

Homotransplantation of Engineered Macrophages with Surface-Modified Nanomedicines for Mitigating Myocardial Ischemia–Reperfusion Injury

Jiahui Cheng, Rifeng Gao, Yang Lyu, Zhi Xiong, Kun Yang, Xinxin Zhao, Xiaoyu Huang, Lingling Xu, Linghuan Guo, Wen Wang, Yuzhuo Li, Weina Ding, Peng Guo, Zhiqiang Ji, Wenli Li, Xu Han, Jin Zhang, Shiteng Suo, Huilin Zhao, Lixian Jiang, Qiang Zhang, Bo Li, Lianming Wu, Yan Zhou

ACS Nano· Volume 19· Issue 27
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Source abstract

Abstract

Immune disorders are intimately involved in the pathological progression of myocardial ischemia-reperfusion injury (MIRI) and exacerbate cardiac cell damage and mitochondria-related metabolic abnormalities. However, low-immunogenic therapeutic strategies targeting the compromised immune-metabolic microenvironment remain a major challenge. Here, we developed a syngenic reparative macrophage system for the selective delivery of nanoscale drugs by modifying liposomes loaded with nano-Pt/Se and c176 onto the surface of M2 macrophages (PS-c@M). In MIRI mice, transplanted PS-c@M was actively recruited to the myocardial ischemic region, maintained long-lasting residence, and responsively released surface-loaded nanomedicines, which in turn synergistically promoted cardiac cell survival and activated extracellular repair and angiogenesis, thus exerting long-term cardioprotective effects. Specifically, PS-c@M significantly inhibited STING-related signaling pathways, thereby remodeling the immune-inflammatory homeostasis, as evidenced by the increased proportions of M2 macrophages, reparative cardiac resident macrophages, and regulatory T cells and the decreased recruitment and infiltration of M1 macrophages and neutrophils. Moreover, PS-c@M facilitated mitochondrial oxidative phosphorylation and suppressed mitochondria-associated ferroptosis and oxidative damage. This study highlights a low-immunogenic targeted therapeutic strategy based on syngenic reparative macrophages as efficient nanomedicine carriers, with potential for development and application in a wide range of immune and inflammation-related diseases.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Extracellular vesicles in disease · Immune cells in cancer · Cardiac Fibrosis and Remodeling

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Radiology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 160, Pujian Road, Pudong District, Shanghai 200127, China

Department of Cardiac Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou 310009, China

Department of Cardiology, Shanghai Fifth People’s Hospital Affiliated to Fudan University, No.801, Heqing Road, Minhang District, Shanghai 200240, China

Institute of Diagnostic and Interventional Radiology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600, Yishan Road, Xuhui District, Shanghai 200233, China

Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88 Jiefang Road, Hangzhou 310009, China

Department of Cardiology, Huadong Hospital Affiliated to Fudan University, No. 221, West Yan’an Road, Jing’an District, Shanghai 200240, China

Shanghai Key Laboratory of Neuro-Ultrasound for Diagnosis and Treatment, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600, Yishan Road, Xuhui District, Shanghai 200233, China

International College of Zhengzhou University, No.75, Daxue Road, Erqi District, Zhengzhou 450000, China

Ministry of Education, Key Laboratory of Anesthesiology (Shanghai Jiao Tong University), No. 160, Pujian Road, Pudong District, Shanghai 200127, China

College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, No. 227, Chongqingnan Road, Huangpu District, Shanghai 200025, China

Funding

National Program for Support of Top-notch Young Professionals · Renji Hospital · Shanghai Municipal Human Resources and Social Security Bureau · Science and Technology Commission of Shanghai Municipality · Shanghai Municipal Health Commission · National Natural Science Foundation of China · Shanghai Shuguang Program

References (59)

Show source-provided references
1. 10.1016/j.jacc.2024.02.05610.1016/j.jacc.2024.02.056 ↗
2. 10.1038/s41392-023-01688-x10.1038/s41392-023-01688-x ↗
3. 10.1038/s41577-021-00524-z10.1038/s41577-021-00524-z ↗
4. 10.1016/j.apsb.2021.05.01110.1016/j.apsb.2021.05.011 ↗
5. 10.1038/nature0731710.1038/nature07317 ↗
6. 10.1161/CIRCULATIONAHA.117.03104610.1161/CIRCULATIONAHA.117.031046 ↗
7. 10.1016/j.cell.2024.05.03110.1016/j.cell.2024.05.031 ↗
8. 10.1016/j.jacc.2024.02.05610.1016/j.jacc.2024.02.056 ↗
9. 10.1016/j.addr.2018.06.01210.1016/j.addr.2018.06.012 ↗
10. 10.1126/science.abm059410.1126/science.abm0594 ↗
11. 10.1161/CIRCRESAHA.124.32521210.1161/CIRCRESAHA.124.325212 ↗
12. 10.1038/s41408-021-00459-710.1038/s41408-021-00459-7 ↗
13. 10.1038/nri244810.1038/nri2448 ↗
14. 10.1038/s41557-023-01280-410.1038/s41557-023-01280-4 ↗
15. 10.1038/s41565-021-00972-710.1038/s41565-021-00972-7 ↗
16. 10.1038/s41551-024-01180-z10.1038/s41551-024-01180-z ↗
17. 10.1038/s41591-024-03406-810.1038/s41591-024-03406-8 ↗
18. 10.1021/acsnano.4c0656510.1021/acsnano.4c06565 ↗
19. 10.1021/acsnano.4c0282510.1021/acsnano.4c02825 ↗
20. 10.1016/j.mattod.2023.03.02410.1016/j.mattod.2023.03.024 ↗
21. 10.1007/s10495-022-01806-010.1007/s10495-022-01806-0 ↗
22. 10.1016/j.cell.2017.11.04810.1016/j.cell.2017.11.048 ↗
23. 10.1097/CCM.000000000000097110.1097/CCM.0000000000000971 ↗
24. 10.1038/s41467-022-33492-610.1038/s41467-022-33492-6 ↗
25. 10.1021/acsnano.2c0555810.1021/acsnano.2c05558 ↗
26. 10.1002/advs.20230316710.1002/advs.202303167 ↗
27. 10.1038/s41586-018-0287-810.1038/s41586-018-0287-8 ↗
28. 10.1021/jacs.2c1105310.1021/jacs.2c11053 ↗
29. 10.1038/nri97810.1038/nri978 ↗
30. 10.1016/j.addr.2015.09.01210.1016/j.addr.2015.09.012 ↗
31. 10.1002/adma.20210534810.1002/adma.202105348 ↗
32. 10.1038/s41551-020-00637-110.1038/s41551-020-00637-1 ↗
33. 10.1016/j.addr.2022.11439410.1016/j.addr.2022.114394 ↗
34. 10.1161/CIRCULATIONAHA.121.05754910.1161/CIRCULATIONAHA.121.057549 ↗
35. 10.1161/CIRCRESAHA.116.30357710.1161/CIRCRESAHA.116.303577 ↗
36. 10.1093/ehjci/jead06510.1093/ehjci/jead065 ↗
37. 10.1097/RLI.000000000000043810.1097/RLI.0000000000000438 ↗
38. 10.1016/j.cell.2020.06.03010.1016/j.cell.2020.06.030 ↗
39. 10.1038/nrcardio.2009.19910.1038/nrcardio.2009.199 ↗
40. 10.1038/s41569-020-0403-y10.1038/s41569-020-0403-y ↗
41. 10.1038/s41580-020-0244-x10.1038/s41580-020-0244-x ↗
42. 10.1038/s41569-023-00946-310.1038/s41569-023-00946-3 ↗
43. 10.1016/j.cell.2017.09.03910.1016/j.cell.2017.09.039 ↗
44. 10.1126/sciadv.abm343610.1126/sciadv.abm3436 ↗
45. 10.7150/thno.6843710.7150/thno.68437 ↗
46. 10.1038/cmi.2015.2310.1038/cmi.2015.23 ↗
47. 10.1093/eurheartj/ehae20510.1093/eurheartj/ehae205 ↗
48. 10.1016/j.cell.2024.04.03710.1016/j.cell.2024.04.037 ↗
49. 10.1016/j.immuni.2022.06.00710.1016/j.immuni.2022.06.007 ↗
50. 10.1093/cvr/cvad12010.1093/cvr/cvad120 ↗
51. 10.1038/s41569-022-00735-410.1038/s41569-022-00735-4 ↗
52. 10.1083/jcb.20210504310.1083/jcb.202105043 ↗
53. 10.1097/CM9.000000000000253310.1097/CM9.0000000000002533 ↗
54. 10.1038/s41556-020-0461-810.1038/s41556-020-0461-8 ↗
55. 10.1016/j.redox.2023.10276010.1016/j.redox.2023.102760 ↗
56. 10.1161/CIRCRESAHA.116.30920210.1161/CIRCRESAHA.116.309202 ↗
57. 10.1021/acsnano.4c0226910.1021/acsnano.4c02269 ↗
58. 10.1016/j.jconrel.2013.11.01610.1016/j.jconrel.2013.11.016 ↗
59. 10.15252/embj.202211290010.15252/embj.2022112900 ↗