DataVXACS NanoPaper
journal article·2024-12-24

Dynamic Covalent Prodrug Nanonetworks via Reaction-Induced Self-Assembly for Periodontitis Treatment

Haoyue Wu, Yong Liu, Yumeng Wang, Yinzi Piao, Zhuojun Meng, Xiaowen Hu, Linqi Shi, Jing Shen, Yuanfeng Li

ACS Nano· Volume 18· Issue 51
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Source abstract

Abstract

Periodontitis is characterized by dysbiotic biofilms, gingival inflammation, and bone resorption, highlighting the urgent need for a comprehensive approach to drug combination therapy. In this study, we introduce dynamic covalent nanonetworks (dcNNWs) synthesized through a one-pot, four-component reaction-induced self-assembly method using polyamines, 2-formylphenylboronic acid, epigallocatechin gallate, and alendronate. The formation of iminoboronate bonds drives the creation of dcNNWs, allowing controlled release in the periodontitis microenvironment. The inclusion of catechol and bisphosphonate imparts exceptional bioadhesive properties to the dcNNWs, enhancing their efficacy in preventing pathogenic bacterial biofilm formation and eliminating mature biofilms. Moreover, the dcNNWs efficiently absorb pathogen-associated molecular patterns and scavenge excess reactive oxygen species, regulating the local immune response and demonstrating anti-inflammatory effects. Additionally, the released polyphenol and alendronate from the dcNNWs alleviated inflammation and enhanced osteogenesis significantly. The detailed synergistic effects of dcNNWs in biofilm eradication, anti-inflammation, and bone remodeling, with minimal impact on healthy tissues, are confirmed in a rat model of periodontitis. With a facile synthesis process, excellent synergistic effects in periodontitis treatment, and biocompatibility, our dcNNWs present a promising and translational solution for the effective management of periodontitis.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterials

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Nanoplatforms for cancer theranostics · Supramolecular Self-Assembly in Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of International VIP Dental Clinic, Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin 300041, China

Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin 300041, China

Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, China

State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China

Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, Translational Medicine Laboratory, The First Affiliated Hospital of Wenzhou Medical University institution, Wenzhou, Zhejiang 325035, China

Funding

University of Chinese Academy of Sciences · National Key Research and Development Program of China · Science and Technology Plan Project of Wenzhou Municipality · Wenzhou Institute of Biomaterials and Engineering · National Natural Science Foundation of China · Natural Science Foundation of Zhejiang Province · Chinese Medical Association · Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province · Key Medical Discipline Special Project · Tianjin Health Science and Technology Project · Tianjin Key Medical Discipline (Specialty) Construction Project

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