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journal article·2024-07-23Open access

Using the High-Entropy Approach to Obtain Multimetal Oxide Nanozymes: Library Synthesis, In Silico Structure–Activity, and Immunoassay Performance

Thuong Phan-Xuan, Simon Schweidler, Steffen Hirte, Moritz Schüller, Ling Lin, Anurag Khandelwal, Kai Wang, Jan Schützke, Markus Reischl, Christian Kübel, Horst Hahn, Gianluca Bello, Johannes Kirchmair, Jasmin Aghassi-Hagmann, Torsten Brezesinski, Ben Breitung, Lea Ann Dailey

ACS Nano· Volume 18· Issue 29
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Abstract

High Resolution Image Download MS PowerPoint Slide High-entropy nanomaterials exhibit exceptional mechanical, physical, and chemical properties, finding applications in many industries. Peroxidases are metalloenzymes that accelerate the decomposition of hydrogen peroxide. This study uses the high-entropy approach to generate multimetal oxide-based nanozymes with peroxidase-like activity and explores their application as sensors in ex vivo bioassays. A library of 81 materials was produced using a coprecipitation method for rapid synthesis of up to 100 variants in a single plate. The A and B sites of the magnetite structure, (AA‘)(BB’B‘‘) 2 O 4, were substituted with up to six different cations (Cu/Fe/Zn/Mg/Mn/Cr). Increasing the compositional complexity improved the catalytic performance; however, substitutions of single elements also caused drastic reductions in the peroxidase-like activity. A generalized linear model was developed describing the relationship between material composition and catalytic activity. Binary interactions between elements that acted synergistically or antagonistically were identified, and a single parameter, the mean interaction effect, was observed to correlate highly with catalytic activity, providing a valuable tool for the design of high-entropy-inspired nanozymes.
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Research context

NanomaterialsCatalysis & surfaces

OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanoparticles: synthesis and applications · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria

Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences (PhaNuSpo), University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria

Institute of Nanotechnology, Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, 76131 Karlsruhe, Germany

Institute of Pharmacy

Martin-Luther-University Halle-Wittenberg

Light Technology Institute, Karlsruhe Institute of Technology, Kaiserstraße 12, 76131 Karlsruhe, Germany

Department of Materials and Earth Sciences, Technical University Darmstadt, Peter-Grünberg-Straße 2, 64287 Darmstadt, Germany

Institute for Automation and Applied Informatics, Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, 76131 Karlsruhe, Germany

Karlsruhe Nano Micro Facility (KNMFi), Karlsruhe Institute of Technology (KIT), Kaiserstraße 12, 76131 Karlsruhe, Germany

Helmholtz Institute Ulm for Electrochemical Energy Storage, Helmholtzstrasse 11, 89081 Ulm, Germany

School of Sustainable Chemical, Biological and Materials Engineering, University of Oklahoma, 201 Stephenson Pkwy, Norman, 73019 Oklahoma, United States

Funding

Karlsruhe Institute of Technology · Deutsche Forschungsgemeinschaft · Universität Wien · China Scholarship Council · Helmholtz Association · Bundesministerium für Bildung, Wissenschaft und Forschung

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