journal article·2024-06-11

Ligand-Induced Atomically Segregation-Tunable Alloy Nanoprobes for Enhanced Magnetic Resonance Imaging

Zeyu Liang, Shangzhi Xie, Qiyue Wang, Bo Zhang, Lin Xiao, Chenhan Wang, Xun Liu, Ying Chen, Shengfei Yang, Hui Du, Yufan Qian, Daishun Ling, Lianming Wu, Fangyuan Li

ACS Nano· Volume 18· Issue 23
Publisher page

Abstract

Bimetallic iron-noble metal alloy nanoparticles have emerged as promising contrast agents for magnetic resonance imaging (MRI) due to their biocompatibility and facile control over the element distribution. However, the inherent surface energy discrepancy between iron and noble metal often leads to Fe atom segregation within the nanoparticle, resulting in limited iron–water molecule interactions and, consequently, diminished relaxometric performance. In this study, we present the development of a class of ligand-induced atomically segregation-tunable alloy nanoprobes (STAN) composed of bimetallic iron–gold nanoparticles. By manipulating the oxidation state of Fe on the particle surface through varying molar ratios of oleic acid and oleylamine ligands, we successfully achieve surface Fe enrichment. Under the application of a 9 T MRI system, the optimized STAN formulation, characterized by a surface Fe content of 60.1 at %, exhibits an impressive r 1 value of 2.28 mM –1 ·s –1, along with a low r 2/ r 1 ratio of 6.2. This exceptional performance allows for the clear visualization of hepatic tumors as small as 0.7 mm in diameter in vivo, highlighting the immense potential of STAN as a next-generation contrast agent for highly sensitive MR imaging.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanocluster Synthesis and Applications · Characterization and Applications of Magnetic Nanoparticles

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, National Center for Translational Medicine, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University, Shanghai 200240, China

Institute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China

World Laureates Association (WLA) Laboratories, Shanghai 201203, China

Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China

Songjiang Institute and Songjiang Hospital, Shanghai Key Laboratory of Emotions and Affective Disorders (LEAD), Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou 310009, China

Funding

National Ten Thousand Talent Program · National Key Research and Development Program of China · Shanghai Science and Technology Development Foundation · Science and Technology Commission of Shanghai Municipality · National Natural Science Foundation of China · Chinese Academy of Sciences · Natural Science Foundation of Zhejiang Province · Program of Shanghai Academic Research Leader · Innovative Research Team of High-level Local Universities in Shanghai

References (67)

Show source-provided references
1. 10.1126/science.abh434010.1126/science.abh4340 ↗
2. 10.1038/s42254-021-00326-110.1038/s42254-021-00326-1 ↗
3. 10.1021/acsnano.7b0307510.1021/acsnano.7b03075 ↗
4. 10.1039/C4CS00345D10.1039/C4CS00345D ↗
5. 10.1038/nri353110.1038/nri3531 ↗
6. 10.1002/adfm.20170039610.1002/adfm.201700396 ↗
7. 10.1038/s41467-022-32615-310.1038/s41467-022-32615-3 ↗
8. 10.1016/j.biomaterials.2014.05.01010.1016/j.biomaterials.2014.05.010 ↗
9. 10.1021/acs.chemrev.8b0036310.1021/acs.chemrev.8b00363 ↗
10. 10.1002/wnan.119810.1002/wnan.1198 ↗
11. 10.1021/acsnano.2c1287410.1021/acsnano.2c12874 ↗
12. 10.1002/adma.20190653910.1002/adma.201906539 ↗
13. 10.1038/s41551-017-0116-710.1038/s41551-017-0116-7 ↗
14. 10.1021/acs.chemrev.5b0011210.1021/acs.chemrev.5b00112 ↗
15. 10.1002/adma.20180456710.1002/adma.201804567 ↗
16. 10.1021/ja203340u10.1021/ja203340u ↗
17. 10.1021/cm201297x10.1021/cm201297x ↗
18. 10.1021/nn900761s10.1021/nn900761s ↗
19. 10.1039/c1nr10173k10.1039/c1nr10173k ↗
20. 10.1021/acs.nanolett.8b0441110.1021/acs.nanolett.8b04411 ↗
21. 10.1002/adfm.20060052510.1002/adfm.200600525 ↗
22. 10.1002/ange.20170338710.1002/ange.201703387 ↗
23. 10.1126/science.287.5460.198910.1126/science.287.5460.1989 ↗
24. 10.1002/anie.20140628110.1002/anie.201406281 ↗
25. 10.1021/nl035004r10.1021/nl035004r ↗
26. 10.1002/adma.20070299410.1002/adma.200702994 ↗
27. 10.1002/anie.20080620910.1002/anie.200806209 ↗
28. 10.1039/C5NR06492A10.1039/C5NR06492A ↗
29. 10.1038/s41467-021-24055-210.1038/s41467-021-24055-2 ↗
30. 10.1039/c1ee01125a10.1039/c1ee01125a ↗
31. 10.1002/cphc.20090005310.1002/cphc.200900053 ↗
32. 10.1016/S0021-9517(03)00057-510.1016/S0021-9517(03)00057-5 ↗
33. 10.1021/cm403172a10.1021/cm403172a ↗
34. 10.1103/PhysRevB.59.1599010.1103/PhysRevB.59.15990 ↗
35. 10.1021/acsnano.1c0150010.1021/acsnano.1c01500 ↗
36. 10.1021/acs.jpcc.9b0394610.1021/acs.jpcc.9b03946 ↗
37. 10.1021/jacs.5b0110010.1021/jacs.5b01100 ↗
38. 10.1021/nn503865210.1021/nn5038652 ↗
39. 10.1021/acs.chemmater.5b0094410.1021/acs.chemmater.5b00944 ↗
40. 10.1016/j.cattod.2010.10.06910.1016/j.cattod.2010.10.069 ↗
41. 10.3390/nano1105122710.3390/nano11051227 ↗
42. 10.1038/s41467-017-00161-y10.1038/s41467-017-00161-y ↗
43. 10.1021/ja804858u10.1021/ja804858u ↗
44. 10.1021/acs.jpcc.5b1103010.1021/acs.jpcc.5b11030 ↗
45. 10.1021/nn305991e10.1021/nn305991e ↗
46. 10.1021/acs.nanolett.9b0017110.1021/acs.nanolett.9b00171 ↗
47. 10.1039/C7NR01406F10.1039/C7NR01406F ↗
48. 10.1038/s41598-020-66706-210.1038/s41598-020-66706-2 ↗
49. 10.1021/am508837v10.1021/am508837v ↗
50. 10.3390/nano1012242410.3390/nano10122424 ↗
51. 10.1039/C7CS00316A10.1039/C7CS00316A ↗
52. 10.1002/(SICI)1099-0682(200003)2000:3<399::AID-EJIC399>3.0.CO;2-B10.1002/(SICI)1099-0682(200003)2000:3<399::AID-EJIC399>3.0.CO;2-B ↗
53. 10.1021/cr980440x10.1021/cr980440x ↗
54. 10.1021/cr00081a00310.1021/cr00081a003 ↗
55. 10.7150/thno.2378910.7150/thno.23789 ↗
56. 10.1038/ncomms326610.1038/ncomms3266 ↗
57. 10.1002/mrm.191005040410.1002/mrm.1910050404 ↗
58. 10.1002/mrm.1005910.1002/mrm.10059 ↗
59. 10.1002/mrm.113510.1002/mrm.1135 ↗
60. 10.1002/adma.20130474410.1002/adma.201304744 ↗
61. 10.1021/cr068445e10.1021/cr068445e ↗
62. 10.1021/ac400366b10.1021/ac400366b ↗
63. 10.1016/j.addr.2022.11448410.1016/j.addr.2022.114484 ↗
64. 10.1021/acsnano.5b0004210.1021/acsnano.5b00042 ↗
65. 10.1039/D2NR03683E10.1039/D2NR03683E ↗
66. 10.1021/nn102587h10.1021/nn102587h ↗
67. 10.1016/j.mattod.2015.11.02510.1016/j.mattod.2015.11.025 ↗