DataVXACS NanoPaper
journal article·2025-07-15

Reversible Adhesive Hydrogel Balancing Conflicting Needs of Strong Adhesion and Painless Removal for Diabetic Joint Wound Healing

Pengyu Song, Qingmei Sun, Xue Liang, Jianrui Li, Junqiu Shi, Yunqing Zhu, Jianzhong Du

ACS Nano· Volume 19· Issue 27
Publisher page
Source abstract

Abstract

Diabetic joint wounds require dressings with strong adhesion, painless removal, and therapeutic effects. We developed DA-Hyd-Doxy, a multifunctional hydrogel, by copolymerizing N -isopropylacrylamide with dopamine-containing zwitterionic poly(amidoamine)s and encapsulating doxycycline. This hydrogel exhibits strong, reversible adhesion, surpassing the Tegaderm film at ∼35 °C, while exposure to 10 °C water for 10 min reduces adhesion to 0 N for painless removal. It also has antioxidant and anti-inflammatory properties, promoting angiogenesis, collagen deposition, and re-epithelialization. Loaded with doxycycline, it achieves nearly 100% bacteria-killing efficiency against E. coli and S. aureus . In vivo studies showed superior wound healing, with DA-Hyd-Doxy achieving near-complete closure (1.1 ± 0.4%) versus Tegaderm (20.2 ± 3.0%). This hydrogel provides a practical solution for infected diabetic joint wounds, offering strong adhesion, painless removal, and multifunctional therapeutic benefits, making it ideal for dynamic wound sites.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersMaterials processing

OpenAlex topics: Wound Healing and Treatments · Surgical Sutures and Adhesives · Hydrogels: synthesis, properties, applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Polymeric Materials, School of Materials Science and Engineering

Tongji University

School of Materials Science and Engineering

East China University of Science and Technology

Department of Gynaecology and Obstetrics, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People’s Hospital, School of Medicine

Department of Orthopaedics, Shanghai Tenth People’s Hospital

Tongji University School of Medicine

Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education, School of Materials Science and Engineering

Funding

National Key Research and Development Program of China · Fundamental Research Funds for the Central Universities · National Natural Science Foundation of China · Interdisciplinary Collaborative Research Project of Tongji University · Innovation Program of Shanghai Municipal Education Commission · Tongcheng Youth Research and Development Fund

References (55)

Show source-provided references
1. 10.1038/nri315010.1038/nri3150 ↗
2. 10.1021/acsnano.1c0420610.1021/acsnano.1c04206 ↗
3. 10.1016/S0140-6736(05)67700-810.1016/S0140-6736(05)67700-8 ↗
4. 10.1002/adhm.20230037510.1002/adhm.202300375 ↗
5. 10.1002/adfm.20210092410.1002/adfm.202100924 ↗
6. 10.1021/acs.chemmater.1c0187210.1021/acs.chemmater.1c01872 ↗
7. 10.1021/acsnano.3c0413410.1021/acsnano.3c04134 ↗
8. 10.1021/acs.chemmater.3c0177610.1021/acs.chemmater.3c01776 ↗
9. 10.1016/j.carbpol.2024.12201410.1016/j.carbpol.2024.122014 ↗
10. 10.1021/acs.biomac.2c0052610.1021/acs.biomac.2c00526 ↗
11. 10.1021/acs.nanolett.4c0186910.1021/acs.nanolett.4c01869 ↗
12. 10.1038/s41467-024-48284-310.1038/s41467-024-48284-3 ↗
13. 10.1002/adfm.20210670510.1002/adfm.202106705 ↗
14. 10.1002/adfm.20211072010.1002/adfm.202110720 ↗
15. 10.1002/adma.20190576710.1002/adma.201905767 ↗
16. 10.1016/j.addr.2017.08.00110.1016/j.addr.2017.08.001 ↗
17. 10.1016/j.carbpol.2023.12117910.1016/j.carbpol.2023.121179 ↗
18. 10.1002/adhm.20230188510.1002/adhm.202301885 ↗
19. 10.1021/acsami.6b0827910.1021/acsami.6b08279 ↗
20. 10.1021/acsami.0c1466510.1021/acsami.0c14665 ↗
21. 10.1002/adfm.20230071010.1002/adfm.202300710 ↗
22. 10.1186/s13620-021-00195-110.1186/s13620-021-00195-1 ↗
23. 10.12968/jowc.2023.32.Sup6a.lxxxvii10.12968/jowc.2023.32.Sup6a.lxxxvii ↗
24. 10.1016/j.cej.2020.12488810.1016/j.cej.2020.124888 ↗
25. 10.1002/smll.20160101710.1002/smll.201601017 ↗
26. 10.1016/j.colsurfb.2018.11.00710.1016/j.colsurfb.2018.11.007 ↗
27. 10.1039/C8CS00508G10.1039/C8CS00508G ↗
28. 10.1002/smll.20190004610.1002/smll.201900046 ↗
29. 10.1021/acsnano.9b0717310.1021/acsnano.9b07173 ↗
30. 10.1021/acsnano.8b0402210.1021/acsnano.8b04022 ↗
31. 10.1016/j.jcis.2019.08.08310.1016/j.jcis.2019.08.083 ↗
32. 10.1016/j.msec.2019.10974510.1016/j.msec.2019.109745 ↗
33. 10.1016/j.actbio.2022.08.04810.1016/j.actbio.2022.08.048 ↗
34. 10.1021/acsnano.1c1104010.1021/acsnano.1c11040 ↗
35. 10.1016/j.biomaterials.2006.12.03010.1016/j.biomaterials.2006.12.030 ↗
36. 10.1021/acsnano.1c0020410.1021/acsnano.1c00204 ↗
37. 10.1002/adhm.20190150210.1002/adhm.201901502 ↗
38. 10.1002/anie.20210103310.1002/anie.202101033 ↗
39. 10.1039/D0MH01985B10.1039/D0MH01985B ↗
40. 10.1002/adhm.20200019810.1002/adhm.202000198 ↗
41. 10.1186/s12951-022-01414-910.1186/s12951-022-01414-9 ↗
42. 10.1002/adhm.20180130710.1002/adhm.201801307 ↗
43. 10.1038/nature0703910.1038/nature07039 ↗
44. 10.1039/C5TB00270B10.1039/C5TB00270B ↗
45. 10.1021/acsami.1c0208910.1021/acsami.1c02089 ↗
46. 10.1016/j.bios.2020.11227510.1016/j.bios.2020.112275 ↗
47. 10.1021/acsami.8b1044610.1021/acsami.8b10446 ↗
48. 10.1016/j.carbpol.2020.11602110.1016/j.carbpol.2020.116021 ↗
49. 10.1016/j.jcis.2018.10.05610.1016/j.jcis.2018.10.056 ↗
50. 10.1021/acsami.5b0837610.1021/acsami.5b08376 ↗
51. 10.1002/adfm.20200944210.1002/adfm.202009442 ↗
52. 10.1007/s13346-015-0258-710.1007/s13346-015-0258-7 ↗
53. 10.1021/bm500625710.1021/bm5006257 ↗
54. 10.1016/j.actbio.2015.08.00610.1016/j.actbio.2015.08.006 ↗
55. 10.1021/acsnano.1c0210210.1021/acsnano.1c02102 ↗