DataVXACS NanoPaper
journal article·2025-04-29Open access

Modulation of Bacterial Iron Homeostasis to Enhance Cuproptosis-like Death for the Treatment of Infected Diabetic Wound

Ge Fang, Qingrong Dong, Xiaomei Shen, Rui Ye, Yuchen Chang, Kefeng Pu, Yujie Tao, Xingfa Gao, Ruhong Zhou, Cuicui Ge

ACS Nano· Volume 19· Issue 16
Publisher pageOpen full text
Source abstract

Abstract

Cuproptosis, an emerging cell death pathway, offers an alternative approach for antimicrobial therapy, but it suffers from deficiencies and health risks. Here, we design hollow Cu-enriched Prussian blue-based nanostructures (Cu-HMPBs) and find that the infected microenvironment facilitates the release of Cu ions from Cu-HMPBs, leading to Cu overload in bacterial cells. Meanwhile, Fe ions in bacterial cells are highly selectively chelated, triggering iron starvation. As a result, the proteotoxic stress and redox imbalance induced by Cu overload are aggravated upon iron starvation, thus remarkably enhancing cuproptosis-like bacterial cell death at extremely low-dose (noncytotoxic) Cu ions. Moreover, we demonstrate the effectiveness of this iron starvation-augmented antimicrobial strategy, and its efficacy is further validated in a methicillin-resistant Staphylococcus aureus (MRSA)-infected diabetic mouse wound model. Collectively, these findings provide a promising and universal strategy on iron starvation sensitizing cuproptosis-like bacterial cell death for combating drug resistance.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Wound Healing and Treatments · Diabetic Foot Ulcer Assessment and Management · Burn Injury Management and Outcomes

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions

Soochow University

College of Medical Imaging

Shanxi Medical University

College of chemistry and materials

Jiangxi Normal University

School of Physics, Institute of Quantitative Biology

Zhejiang University

Groningen Biomolecular Sciences and Biotechnology Institute

University of Groningen

Agnes Ginges Centre for Molecular Cardiology at Centenary Institute

The University of Sydney

Nano-Bio-Chem Centre

Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences

Laboratory of Theoretical and Computational Nanoscience

National Center for Nanoscience and Technology of China

MOE Key Laboratory of Biosystems Homeostasis & Protection, College of Life Sciences

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China · Natural Science Foundation of Jiangxi Province · Postdoctoral Science Foundation of Jiangsu Province · Shanghai Artificial Intelligence Lab · National Center of Technology Innovation for Biopharmaceuticals · Natural Science Foundation of the Jiangsu Higher Education Institutes · Zhangjiang National Innovation Demonstration Zone · Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions · Shanghai Institute for Advanced Study, Zhejiang University

References (50)

Show source-provided references
1. 10.1089/wound.2015.063510.1089/wound.2015.0635 ↗
2. 10.1038/s41565-024-01660-y10.1038/s41565-024-01660-y ↗
3. 10.1016/j.addr.2018.03.00210.1016/j.addr.2018.03.002 ↗
4. 10.1038/s41467-022-35050-610.1038/s41467-022-35050-6 ↗
5. 10.1038/s41467-019-09946-910.1038/s41467-019-09946-9 ↗
6. 10.1126/science.abf052910.1126/science.abf0529 ↗
7. 10.1002/adma.20230343210.1002/adma.202303432 ↗
8. 10.1002/adfm.20230819710.1002/adfm.202308197 ↗
9. Umasankareswari T. · 2020 · 12510.1016/B978-0-12-819943-5.00006-3 ↗
10. 10.1016/j.jinorgbio.2016.02.01210.1016/j.jinorgbio.2016.02.012 ↗
11. 10.1002/adfm.20220501310.1002/adfm.202205013 ↗
12. 10.1002/ange.20231969010.1002/ange.202319690 ↗
13. 10.1126/scitranslmed.aat752010.1126/scitranslmed.aat7520 ↗
14. 10.1038/nrmicro283610.1038/nrmicro2836 ↗
15. 10.1038/s42255-022-00723-510.1038/s42255-022-00723-5 ↗
16. 10.1002/adma.20200145210.1002/adma.202001452 ↗
17. 10.1002/adma.20200054210.1002/adma.202000542 ↗
18. 10.1038/nchembio.7210.1038/nchembio.72 ↗
19. 10.1002/adfm.20160579510.1002/adfm.201605795 ↗
20. 10.1007/s00018030000110.1007/s000180300001 ↗
21. 10.1038/s41467-024-45619-y10.1038/s41467-024-45619-y ↗
22. 10.1002/adma.20220796110.1002/adma.202207961 ↗
23. 10.1128/AAC.01519-1210.1128/AAC.01519-12 ↗
24. 10.1016/j.tips.2021.05.00110.1016/j.tips.2021.05.001 ↗
25. 10.1038/s41564-017-0037-y10.1038/s41564-017-0037-y ↗
26. 10.1126/sciadv.adg420510.1126/sciadv.adg4205 ↗
27. 10.1038/nature1409810.1038/nature14098 ↗
28. 10.1038/s41467-019-12429-610.1038/s41467-019-12429-6 ↗
29. 10.1002/smll.20210713710.1002/smll.202107137 ↗
30. 10.1093/bioinformatics/btt65610.1093/bioinformatics/btt656 ↗
31. 10.1186/s13059-014-0550-810.1186/s13059-014-0550-8 ↗
32. 10.1093/nar/gkh03610.1093/nar/gkh036 ↗
33. 10.1093/nar/28.1.2710.1093/nar/28.1.27 ↗
34. 10.1002/adma.20230343210.1002/adma.202303432 ↗
35. 10.1103/PhysRevB.59.175810.1103/PhysRevB.59.1758 ↗
36. 10.1016/0927-0256(96)00008-010.1016/0927-0256(96)00008-0 ↗
37. 10.1103/PhysRevB.54.1116910.1103/PhysRevB.54.11169 ↗
38. 10.1103/PhysRevLett.77.386510.1103/PhysRevLett.77.3865 ↗
39. 10.1103/PhysRevB.50.1795310.1103/PhysRevB.50.17953 ↗
40. 10.1002/jcc.2635310.1002/jcc.26353 ↗
41. 10.1103/PhysRevB.40.361610.1103/PhysRevB.40.3616 ↗
42. 10.1038/nnano.2013.12510.1038/nnano.2013.125 ↗
43. 10.1063/1.240842010.1063/1.2408420 ↗
44. 10.1063/1.32869310.1063/1.328693 ↗
45. 10.1021/jp973084f10.1021/jp973084f ↗
46. 10.1063/1.44586910.1063/1.445869 ↗
47. 10.1063/1.46439710.1063/1.464397 ↗
48. 10.1002/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H10.1002/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H ↗
49. 10.1021/ct700301q10.1021/ct700301q ↗
50. 10.1002/jcc.2008410.1002/jcc.20084 ↗