journal article·2024-09-24

Framework Nucleic Acids Loaded with Quercetin: Protecting Retinal Neurovascular Unit via the Protein Kinase B/Heme Oxygenase-1 Pathway

Yili Jin, Xiaodi Zhou, Limei Chen, Xiaoxiao Xu, Wenjia Yan, Qiong Wang, Yunfeng Lin, Xiaoyan Ding

ACS Nano· Volume 18· Issue 38
Publisher page

Abstract

Retinal neovascular disease is a leading cause of vision loss and blindness globally. It occurs when abnormal new blood vessels form in the retina. In this study, we utilized tetrahedral framework nucleic acids (tFNAs) as vehicles to load quercetin (QUE), a small-molecule flavonoid, forming a deoxyribonucleic acid (DNA) nanocomplex, tFNAs-QUE. Our data show this nanocomplex inhibits pathological neovascularization, reduces the area of retinal nonperfusion area, protects retinal neurons, and preserves the visual function. Further, we discovered that tFNAs-QUE selectively upregulates the AKT/Nrf2/HO-1 signaling pathway, which can suppress pathological vascular growth and exert antioxidative effects. Therefore, this study presents a promising small-molecule-loading mechanism for the treatment of ischemic retinal diseases.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Retinal Diseases and Treatments · Glaucoma and retinal disorders · Retinopathy of Prematurity Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center

Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science

Innovative Institute of Chinese Medicine and Pharmacy

Chengdu University of Traditional Chinese Medicine

State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology

Sichuan University

Sichuan Provincial Engineering Research Center of Oral Biomaterials

National Center for Translational Medicine

Shanghai Jiao Tong University

Funding

Basic and Applied Basic Research Foundation of Guangdong Province · Guangzhou Municipal Science and Technology Bureau · National Natural Science Foundation of China · Guangdong Province

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