journal article·2024-06-18

Photoactivated Gas-Generating Nanocontrast Agents for Long-Term Ultrasonic Imaging-Guided Combined Therapy of Tumors

Binbin Chu, Zhiming Chen, Xiaofeng Wu, Haoliang Shi, Xiangbowen Jin, Bin Song, Mingyue Cui, Yadan Zhao, Yingying Zhao, Yao He, Houyu Wang, Fenglin Dong

ACS Nano· Volume 18· Issue 24
Publisher page

Abstract

To date, long-term and continuous ultrasonic imaging for guiding the puncture biopsy remains a challenge. In order to address this issue, a multimodality imaging and therapeutic method was developed in the present study to facilitate long-term ultrasonic and fluorescence imaging-guided precision diagnosis and combined therapy of tumors. In this regard, certain types of photoactivated gas-generating nanocontrast agents (PGNAs), capable of exhibiting both ultrasonic and fluorescence imaging ability along with photothermal and sonodynamic function, were designed and fabricated. The advantages of these fabricated PGNAs were then utilized against tumors in vivo, and high therapeutic efficacy was achieved through long-term ultrasonic imaging-guided treatment. In particular, the as-prepared multifunctional PGNAs were applied successfully for the fluorescence-based determination of patient tumor samples collected through puncture biopsy in clinics, and superior performance was observed compared to the clinically used SonoVue contrast agents that are incapable of specifically distinguishing the tumor in ex vivo tissues.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Photoacoustic and Ultrasonic Imaging · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Suzhou Key Laboratory of Nanotechnology and Biomedicine, Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano and Soft Materials (FUNSOM) and Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO−CIC), Soochow University, Suzhou 215123 China

Department of Ultrasound, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China

Macao Translational Medicine Center, Macau University of Science and Technology, Taipa, 999078 Macau SAR, China

Macao Institute of Materials Science and Engineering, Macau University of Science and Technology, Taipa, 999078 Macau SAR, China

Funding

Collaborative Innovation Center of Suzhou Nano Science and Technology · National Key Research and Development Program of China · Jiangsu Provincial Department of Education · Fundo para o Desenvolvimento das Ciências e da Tecnologia · National Natural Science Foundation of China · Priority Academic Program Development of Jiangsu Higher Education Institutions · Higher Education Discipline Innovation Project

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