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journal article·2024-07-17Open access

Cerium Vanadate Nanozyme with pH-Dependent Dual Enzymatic Activity for Glioblastoma Targeted Therapy and Postradiotherapy Damage Protection

Xiao Han, Boyan Li, Wenhan Wang, Bowen Feng, Qilin Tang, Yanhua Qi, Rongrong Zhao, Wei Qiu, Shulin Zhao, Ziwen Pan, Xiaofan Guo, Hao Du, Jichuan Qiu, Hong Liu, Gang Li, Hao Xue

ACS Nano
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Abstract

High Resolution Image Download MS PowerPoint Slide Nanocatalytic therapy is an emerging technology that uses synthetic nanoscale enzyme mimics for biomedical treatment. However, in the field of neuroscience, achieving neurological protection while simultaneously killing tumor cells is a technical challenge. Herein, we synthesized a biomimic and translational cerium vanadate (CeVO 4 ) nanozyme for glioblastoma (GBM) therapy and the repair of brain damage after GBM ionizing radiation (IR). This system exhibited pH dependence: it showed potent Superoxide dismutase (SOD) enzyme activity in a neutral environment and Peroxidase (POD) enzyme activity in an acidic environment. In GBM cells, this system acted in lysosomes, causing cellular damage and reactive oxygen species (ROS) accumulation; in neuronal cells, this nanozyme could undergo lysosomal escape and nanozyme aggregation with mitochondria, reversing the mitochondrial damage caused by IR and restoring the expression level of the antiapoptotic BCL-2 protein. Mechanistically, we believe that this distribution difference is related to the specific uptake internalization mechanism and lysosomal repair pathway in neurons, and ultimately led to the dual effect of tumor killing and nerve repair in the in vivo model. In summary, this study provides insight into the repair of brain damage after GBM radiation therapy.
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Research context

Nanomaterials

OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250012, P. R. China

Shandong Key Laboratory of Brain Function Remodeling, Jinan, Shandong 250012, P. R. China

Department of Neurosurgery, Children’s Hospital Affiliated to Shandong University, Jinan Children’s Hospital, Jinan, Shandong 250001, P.R. China

Department of Cell Biology, University of Connecticut School of Medicine, Farmington, Connecticut 06032, United States

State Key Laboratory of Crystal Materials, Shandong University, Jinan, Shandong 250100, P. R. China

Institute for Advanced Interdisciplinary Research (IAIR), University of Jinan, Jinan, Shandong 250022, P. R. China

Funding

Ministry of Science and Technology of the People's Republic of China · China Postdoctoral Science Foundation · Taishan Scholar Project of Shandong Province · State Key Laboratory of Crystal Materials · Fundamental Research Funds for the Central Universities · National Natural Science Foundation of China · Natural Science Foundation of Shandong Province · Jinan Science and Technology Bureau

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