journal article·2024-10-29

Aggregation-Induced Emission Luminogen Based Wearable Visible-Light Penetrator for Deep Photodynamic Therapy

Kun Zhou, Ying Yu, Letian Xu, Siyuan Wang, Zhuojian Li, Yong Liu, Ryan T. K. Kwok, Jianwei Sun, Jacky W. Y. Lam, Gang He, Zheng Zhao, Ben Zhong Tang

ACS Nano· Volume 18· Issue 43
Publisher page

Abstract

Photodynamic therapy (PDT) has emerged as a preferred nonsurgical treatment in clinical applications due to its capacity to selectively eradicate diseased tissues while minimizing damage to normal tissue. Nevertheless, its clinical efficacy is constrained by the limited penetration of visible light. Although near-infrared (NIR) lasers offer enhanced tissue penetration, the dearth of suitable photosensitizers and a pronounced imaging-treatment disparity pose challenges. Additionally, clinical implementation via optical fiber implantation carries infection risks and necessitates minimally invasive surgery, contradicting PDT’s noninvasive advantage. In this study, we introduce a brilliant approach utilizing aggregation-induced emission luminogens (AIEgen) to develop a visible-light penetrator (VLP), coupled with wireless light emitting diodes (LEDs), enabling deep photodynamic therapy. We validate the therapeutic efficacy of this visible-light penetrator in tissues inaccessible to conventional PDT, demonstrating significant suppression of inflammatory diffusion in vivo using AIEgen TBPPM loaded within the VLP, which exhibits a transmittance of 86% in tissues with a thickness of 3 mm. This innovative visible-light penetrator effectively overcomes the substantial limitations of PDT in clinical settings and holds promise for advancing phototherapy.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Science and Engineering, Clinical Translational Research Center of Aggregation-Induced Emission, The Second Affiliated Hospital, School of Medicine, Shenzhen Institute of Aggregate Science and Technology

The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen)

Department of Chemistry, The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science, State Key Laboratory of Molecular Neuroscience, and Department of Biological and Chemical Engineering

The Hong Kong University of Science and Technology

Hohai University (Changzhou Campus)

State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates

South China University of Technology

AIE Institute, Guangzhou Development District, Huangpu, Guangzhou, Guangdong 510530, China

Frontier Institute of Science and Technology

Xi’an Jiaotong University

Funding

National Key Research and Development Program of China · Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of Technology · Basic and Applied Basic Research Foundation of Guangdong Province · Science, Technology and Innovation Commission of Shenzhen Municipality · Innovation and Technology Commission · Guangzhou Municipal Science and Technology Project · National Natural Science Foundation of China · Shenzhen Key Laboratory of Functional Aggregate Materials, Chinese University of Hong Kong · Guangzhou Science and Technology Planning Project

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