journal article·2024-10-29

Enhanced Peroxidase-like Activity of Ruthenium-Modified Single-Atom-Thick A Layers in MAX Phases for Biomedical Applications

Shuairu Zhu, Chao He, Huiling Tan, Chaoyin Xie, Pengte Ma, Fei Fang, Youbing Li, Mao Chen, Weihua Zhuang, Hongwei Xu, Mei Yang, Han Luo, Yongchao Yao, Wenchuang Walter Hu, Qing Huang, Xuping Sun, Binwu Ying

ACS Nano· Volume 18· Issue 43
Publisher page

Abstract

Nanozymes have demonstrated significant potential as promising alternatives to natural enzymes in biomedical applications. However, their lower catalytic activity compared to that of natural enzymes has limited their practical utility. Addressing this challenge necessitates the development of innovative enzymatic systems capable of achieving specific activity levels of natural enzymes. In this study, we focus on enhancing the catalytic performance of nanozymes by introducing Ru atoms into the single-atom-thick A layer of the V 2 SnC MAX phase, resulting in the formation of V 2 (Sn 0.8 Ru 0.2 )C with Ru single-atom sites. The V 2 (Sn 0.8 Ru 0.2 )C MAX phase demonstrated an exceptional peroxidase-like specific activity of up to 1792.6 U mg –1, surpassing the specific activity of a previously reported horseradish peroxidase (HRP). Through X-ray photoelectron spectroscopy (XPS) and density functional theory (DFT) investigations, it has been revealed that both the V 2 C atom layers and single-atom-thick Sn readily accept a negative charge from Ru, leading to a reduction of the energy barrier for H 2 O 2 adsorption. This discovery has enabled the successful application of V 2 (Sn 0.8 Ru 0.2 )C in the development of a lateral flow immunoassay for heart failure biomarkers, achieving a detection sensitivity of 4 pg mL –1 . Additionally, V 2 (Sn 0.8 Ru 0.2 )C demonstrated exceptional broad-spectrum antibacterial efficacy. This study lays the groundwork for the precise design of MAX phase-based nanozymes with high specific activity, offering a viable alternative to natural enzymes for various applications.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Advanced Nanomaterials in Catalysis · MXene and MAX Phase Materials · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Laboratory Medicine/Clinical Laboratory Medicine Research Center

West China Hospital, Sichuan University

Sichuan Clinical Research Center for Laboratory Medicine

Institute of Fundamental and Frontier Sciences

University of Electronic Science and Technology of China

Precision Medicine Translational Research Center, Med-X Center for Manufacturing

State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions

Soochow University

College of Digital Technology and Engineering

Ningbo University of Finance and Economics

Department of Cardiology, Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases

Zhejiang Key Laboratory of Data-Driven High-Safety Energy Materials and Applications, Ningbo Key Laboratory of Special Energy Materials and Chemistry

Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences

High Altitude Medical Center

Funding

West China Hospital, Sichuan University · Natural Science Foundation of Ningbo Municipality · Ministry of Science and Technology of the People's Republic of China · Fundamental Research Funds for the Central Universities · National Natural Science Foundation of China · Natural Science Foundation of Zhejiang Province

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