journal article·2024-02-27

Local Electric Potential-Driven Nanofluidic Ion Transport for Ultrasensitive Biochemical Sensing

Qun Ma, Wenjing Chu, Xianliang Nong, Jing Zhao, Hong Liu, Qiujiao Du, Jielin Sun, Jianlei Shen, Si-Min Lu, Meihua Lin, Yu Huang, Fan Xia

ACS Nano· Volume 18· Issue 8
Publisher page

Abstract

Nanofluidic biosensors have been widely used for detection of analytes based on the change of system resistance before and after target-probe interactions. However, their sensitivity is limited when system resistance barely changes toward low-concentration targets. Here, we proposed a strategy to address this issue by means of target-induced change of local membrane potential under relatively unchanged system resistance. The local membrane potential originated from the directional diffusion of photogenerated carriers across nanofluidic biosensors and gated photoinduced ionic current signal before and after target-probe interactions. The sensitivity of such biosensors for the detection of biomolecules such as circulating tumor DNA (ctDNA) and lysozyme exceeds that of applying a traditional strategy by more than 3 orders of magnitude under unchanged system resistance. Such biosensors can specifically detect the small molecule biomarker in the blood sample between prostate cancer patients and healthy humans. The key advantages of such nanofluidic biosensors are therefore complementary to traditional nanofluidic biosensors, with potential applications in a point-of-care analytical tool.
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Research context

OpenAlex topics: Nanopore and Nanochannel Transport Studies · Fuel Cells and Related Materials · Microfluidic and Capillary Electrophoresis Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Biogeology and Environmental Geology, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, P. R. China

Department of Chemical Engineering, Graduate School of Engineering, Osaka Metropolitan University, Osaka 599-8531, Japan

Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China

School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China

Molecular Sensing and Imaging Center, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China

Funding

Israel Science Foundation · National Key Research and Development Program of China · Basic and Applied Basic Research Foundation of Guangdong Province · Natural Science Foundation of Hubei Province · National Natural Science Foundation of China

References (46)

Show source-provided references
1. 10.1038/s41565-022-01193-210.1038/s41565-022-01193-2 ↗
2. 10.1038/s41578-020-0229-610.1038/s41578-020-0229-6 ↗
3. 10.1002/anie.20220376910.1002/anie.202203769 ↗
4. 10.1016/j.matt.2022.11.02610.1016/j.matt.2022.11.026 ↗
5. 10.1021/acs.analchem.3c0380610.1021/acs.analchem.3c03806 ↗
6. 10.1021/acs.analchem.3c0522810.1021/acs.analchem.3c05228 ↗
7. 10.1021/ja901120f10.1021/ja901120f ↗
8. 10.1016/j.trac.2019.04.01410.1016/j.trac.2019.04.014 ↗
9. 10.1002/anie.20220997010.1002/anie.202209970 ↗
10. 10.1021/acs.analchem.0c0386810.1021/acs.analchem.0c03868 ↗
11. 10.1002/anie.20180332410.1002/anie.201803324 ↗
12. 10.1021/acs.analchem.2c0421610.1021/acs.analchem.2c04216 ↗
13. 10.1021/jacs.7b1173210.1021/jacs.7b11732 ↗
14. 10.1038/s41467-021-21507-710.1038/s41467-021-21507-7 ↗
15. 10.1021/acs.analchem.0c0309010.1021/acs.analchem.0c03090 ↗
16. 10.1038/nnano.2014.2810.1038/nnano.2014.28 ↗
17. 10.1002/adma.20170332310.1002/adma.201703323 ↗
18. 10.1021/acs.analchem.2c0369010.1021/acs.analchem.2c03690 ↗
19. 10.1021/ac990615i10.1021/ac990615i ↗
20. 10.1038/nnano.2008.610.1038/nnano.2008.6 ↗
21. 10.1021/acsnano.1c0858210.1021/acsnano.1c08582 ↗
22. 10.1126/science.114612610.1126/science.1146126 ↗
23. 10.1038/nnano.2009.33210.1038/nnano.2009.332 ↗
24. 10.1002/adma.20190148310.1002/adma.201901483 ↗
25. 10.1016/j.trac.2021.11642510.1016/j.trac.2021.116425 ↗
26. 10.1039/D2CS00894G10.1039/D2CS00894G ↗
27. 10.1038/s41583-019-0197-210.1038/s41583-019-0197-2 ↗
28. 10.1038/s41593-022-01094-610.1038/s41593-022-01094-6 ↗
29. 10.1038/s41467-019-09178-x10.1038/s41467-019-09178-x ↗
30. 10.1002/anie.20191651610.1002/anie.201916516 ↗
31. 10.1002/anie.20200508410.1002/anie.202005084 ↗
32. 10.1021/acs.nanolett.2c0450710.1021/acs.nanolett.2c04507 ↗
33. 10.1016/j.joule.2019.04.01110.1016/j.joule.2019.04.011 ↗
34. 10.1002/anie.20220269810.1002/anie.202202698 ↗
35. 10.31635/ccschem.021.20210129710.31635/ccschem.021.202101297 ↗
36. 10.1002/smll.20190535510.1002/smll.201905355 ↗
37. 10.1002/anie.20190783310.1002/anie.201907833 ↗
38. 10.1038/s41563-018-0038-010.1038/s41563-018-0038-0 ↗
39. 10.1038/s41560-018-0194-010.1038/s41560-018-0194-0 ↗
40. 10.1002/anie.20201432910.1002/anie.202014329 ↗
41. 10.1002/smll.20200122310.1002/smll.202001223 ↗
42. 10.1021/acs.analchem.0c0234110.1021/acs.analchem.0c02341 ↗
43. 10.1021/acs.analchem.1c0044410.1021/acs.analchem.1c00444 ↗
44. 10.1021/acs.analchem.1c0119710.1021/acs.analchem.1c01197 ↗
45. 10.1021/ja401957210.1021/ja4019572 ↗
46. 10.1126/science.aao675010.1126/science.aao6750 ↗