journal article·2024-01-09

Intravenous Senescent Erythrocyte Vaccination Modulates Adaptive Immunity and Splenic Complement Production

Yan He, Chuanxu Cheng, Yuheng Liu, Fang-Man Chen, Yinglu Chen, Chao Yang, Zhibin Zhao, Jianati Dawulieti, Zikun Shen, Yunjiao Zhang, Jin-Zhi Du, Shan Guan, Dan Shao

ACS Nano· Volume 18· Issue 1
Publisher page

Abstract

Targeted delivery of vaccines to the spleen remains a challenge. Inspired by the erythrophagocytotic process in the spleen, we herein report that intravenous administration of senescent erythrocyte-based vaccines profoundly alters their tropism toward splenic antigen-presenting cells (APCs) for imprinting adaptive immune responses. Compared with subcutaneous inoculation, intravenous vaccination significantly upregulated splenic complement expression in vivo and demonstrated synergistic antibody killing in vitro . Consequently, intravenous senescent erythrocyte vaccination produces potent SARS-CoV-2 antibody-neutralizing effects, with potential protective immune responses. Moreover, the proposed senescent erythrocyte can deliver antigens from resected tumors and adjuvants to splenic APCs, thereby inducing a personalized immune reaction against tumor recurrence after surgery. Hence, our findings suggest that senescent erythrocyte-based vaccines can specifically target splenic APCs and evoke adaptive immunity and complement production, broadening the tools for modulating immunity, helping to understand adaptive response mechanisms to senescent erythrocytes better, and developing improved vaccines against cancer and infectious diseases.
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Research context

OpenAlex topics: COVID-19 Impact on Reproduction · Immune responses and vaccinations · Neonatal Respiratory Health Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou, Guangdong 511442, China

National Engineering Research Center of Immunological Products, Third Military Medical University, Chongqing 400038, China

Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China

School of Medicine, South China University of Technology, Guangzhou International Campus, Guangzhou, Guangdong 510006, China

Department of Orthopedics, Academy of Orthopedics-Guangdong Province, Orthopedic Hospital of Guangdong Province, Guangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510665, China

Medical Research Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510080, China

National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, Guangdong 510006, China

Funding

Ministry of Science and Technology of the People's Republic of China · Natural Science Foundation of Chongqing Municipality · Fundamental Research Funds for the Central Universities · National Natural Science Foundation of China · Chongqing Talents: Exceptional Young Talents Project · Guangzhou Basic and Applied Basic Research Foundation

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