journal article·2024-06-18Open access

A Wearable Self-Charging Electroceutical Device for Bacteria-Infected Wound Healing

Yan Zhou, Xuenan Ma, Changchun Yu, Yaping Tian, Qin Liang, Meiying Xin, Peng Sun, Fangmeng Liu, Danming Chao, Xiaoteng Jia, Caiyun Wang, Geyu Lu

ACS Nano· Volume 18· Issue 24

Abstract

The prolonged wound-healing process caused by pathogen infection remains a major public health challenge. The developed electrical antibiotic administration typically requires metal electrodes wired to a continuous power supply, restricting their use beyond clinical environments. To obviate the necessity for antibiotics and an external power source, we have developed a wearable synergistic electroceutical device composed of an air self-charging Zn battery. This battery integrates sustained tissue regeneration and antibacterial modalities while maintaining more than half of the initial capacity after ten cycles of chemical charging. In vitro bacterial/cell coculture with the self-charging battery demonstrates inhibited bacterial activity and enhanced cell function by simulating the endogenous electric field and dynamically engineering the microenvironment with released chemicals. This electroceutical device provides accelerated healing of a bacteria-infected wound by stimulating angiogenesis and modulating inflammation, while effectively inhibiting bacterial growth at the wound site. Considering the simple structure and easy operation for long-term treatment, this self-charging electroceutical device offers great potential for personalized wound care.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Planarian Biology and Electrostimulation · Neuroscience and Neural Engineering · Plant and Biological Electrophysiology Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, China

School of Ophthalmology and Optometry, School of Biomedical Engineering, State Key Laboratory of Ophthalmology, Optometry, and Vision Science, Wenzhou Medical University, Wenzhou 325027, China

Department of Dermatology and Venerology of the First Hospital, Jilin University, Changchun 130021, China

College of Chemistry, Jilin University, Changchun 130012, China

Jilin Provincial Key Laboratory of Pediatric Neurology, Department of Pediatric Neurology, The First Hospital of Jilin University, Changchun 130021, China

International Center of Future Science, Jilin University, Changchun 130012, China

Intelligent Polymer Research Institute, AIIM Facility, University of Wollongong, Wollongong, New South Wales 2522, Australia

Funding

Changchun Science and Technology Planning Project · China Postdoctoral Science Foundation · Department of Science and Technology of Jilin Province · National Natural Science Foundation of China

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