DataVXACS NanoPaper
journal article·2023-10-10

Nanocrystalline Cellulose Modulates Dysregulated Intestinal Barriers in Ulcerative Colitis

Mingzheng Wang, Ruitao Cha, Wenshuai Hao, Xingyu Jiang

ACS Nano· Volume 17· Issue 19
Publisher page
Source abstract

Abstract

Ulcerative colitis (UC) is a recurrent chronic inflammation of the colon with increasing incidence and prevalence, which could increase the risk of colorectal cancer. It is urgent to find an effective method with few side effects. Nanocrystalline cellulose (NCC), which is from plant fibers, has a good biocompatibility and high biosafety. Herein, we used NCC to treat UC and evaluated its treatment effect by the disease activity index, intestinal pathology, inflammatory cytokines, tight junction proteins, and mucins. We studied the impact of NCC on mucin expression and gut microbiota to discuss the therapeutic mechanism. NCC can effectively treat UC by regulating the MAPK pathway of mucin 2 and the relative abundance of Akkermansia and Odoribacter, which could not cause the body damage. NCC could not cause body damage compared to the medications, while it had a better effect on the regulation of MUC2 compared to the present drug substitutes. NCC is a practical alternative for the treatment of UC.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterials

OpenAlex topics: Gut microbiota and health · Barrier Structure and Function Studies · Inflammatory Bowel Disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Laboratory of Theoretical and Computational Nanoscience, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, P. R. China

Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences (Beijing), Beijing 100083, P. R. China

Shenzhen Key Laboratory of Smart Healthcare Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, P. R. China

Funding

Guangdong Provincial Introduction of Innovative Research and Development Team · National Key Research and Development Program of China · Science and Technology Foundation of Shenzhen City · National Natural Science Foundation of China · Shenzhen Key Laboratory of Smart Healthcare Engineering · Guangdong Major Talent Introduction Project · Tencent Foundation · Guangdong Provincial Key Laboratory of Advanced Biomaterials

References (61)

Show source-provided references
1. 10.1038/s41563-019-0462-910.1038/s41563-019-0462-9 ↗
2. 10.1021/acsnano.9b0912510.1021/acsnano.9b09125 ↗
3. 10.1038/nrgastro.2015.15010.1038/nrgastro.2015.150 ↗
4. 10.1016/S2468-1253(19)30333-410.1016/S2468-1253(19)30333-4 ↗
5. 10.1073/pnas.211270411810.1073/pnas.2112704118 ↗
6. 10.1021/acsnano.0c1072410.1021/acsnano.0c10724 ↗
7. 10.1016/j.biomaterials.2022.12141010.1016/j.biomaterials.2022.121410 ↗
8. 10.1016/j.jconrel.2022.05.02510.1016/j.jconrel.2022.05.025 ↗
9. 10.1016/S0140-6736(19)32545-010.1016/S0140-6736(19)32545-0 ↗
10. 10.1021/acsnano.7b0134610.1021/acsnano.7b01346 ↗
11. 10.1002/advs.20217011510.1002/advs.202170115 ↗
12. 10.1126/sciadv.ade507910.1126/sciadv.ade5079 ↗
13. 10.1021/acsnano.3c0003210.1021/acsnano.3c00032 ↗
14. 10.1038/s41467-022-35579-610.1038/s41467-022-35579-6 ↗
15. 10.1126/sciadv.abf067710.1126/sciadv.abf0677 ↗
16. 10.1002/advs.20210400610.1002/advs.202104006 ↗
17. 10.1038/nature2517210.1038/nature25172 ↗
18. 10.1039/D1NH00315A10.1039/D1NH00315A ↗
19. 10.1038/nature0541410.1038/nature05414 ↗
20. 10.1073/pnas.040707610110.1073/pnas.0407076101 ↗
21. 10.1021/acsnano.2c0580910.1021/acsnano.2c05809 ↗
22. 10.1038/s41586-021-03967-510.1038/s41586-021-03967-5 ↗
23. 10.1021/acsnano.9b0100210.1021/acsnano.9b01002 ↗
24. 10.1016/j.cej.2022.13497610.1016/j.cej.2022.134976 ↗
25. 10.1016/j.ijbiomac.2020.07.19110.1016/j.ijbiomac.2020.07.191 ↗
26. 10.1136/gutjnl-2020-32226010.1136/gutjnl-2020-322260 ↗
27. 10.1126/science.abb159010.1126/science.abb1590 ↗
28. 10.1016/j.cej.2021.13171510.1016/j.cej.2021.131715 ↗
29. 10.1021/acsnano.3c0165610.1021/acsnano.3c01656 ↗
30. 10.1053/j.gastro.2021.08.04710.1053/j.gastro.2021.08.047 ↗
31. 10.1016/j.cej.2021.13046410.1016/j.cej.2021.130464 ↗
32. 10.1016/j.nantod.2017.08.00610.1016/j.nantod.2017.08.006 ↗
33. 10.1016/j.addr.2021.11410110.1016/j.addr.2021.114101 ↗
34. 10.1038/nrgastro.2016.19710.1038/nrgastro.2016.197 ↗
35. 10.1016/j.cell.2016.10.04310.1016/j.cell.2016.10.043 ↗
36. 10.1016/j.carbpol.2020.11646610.1016/j.carbpol.2020.116466 ↗
37. 10.1016/j.carbpol.2012.01.02610.1016/j.carbpol.2012.01.026 ↗
38. 10.1016/j.biomaterials.2019.11947410.1016/j.biomaterials.2019.119474 ↗
39. 10.1002/adhm.20180033410.1002/adhm.201800334 ↗
40. 10.1021/acsami.1c0630810.1021/acsami.1c06308 ↗
41. 10.1007/s10570-014-0397-x10.1007/s10570-014-0397-x ↗
42. 10.1007/s10570-022-04514-910.1007/s10570-022-04514-9 ↗
43. 10.1038/nprot.2007.4110.1038/nprot.2007.41 ↗
44. 10.1053/j.gastro.2006.04.02010.1053/j.gastro.2006.04.020 ↗
45. 10.1053/j.gastro.2012.10.04310.1053/j.gastro.2012.10.043 ↗
46. 10.1073/pnas.95.10.571810.1073/pnas.95.10.5718 ↗
47. 10.1074/jbc.M20035320010.1074/jbc.M200353200 ↗
48. 10.1038/s41575-022-00631-910.1038/s41575-022-00631-9 ↗
49. 10.1128/Spectrum.00730-2110.1128/Spectrum.00730-21 ↗
50. 10.1016/j.chom.2021.03.01610.1016/j.chom.2021.03.016 ↗
51. 10.1136/gut.25.8.80510.1136/gut.25.8.805 ↗
52. 10.1093/femsre/fuaa05210.1093/femsre/fuaa052 ↗
53. 10.1038/3507859910.1038/35078599 ↗
54. 10.1038/s41591-019-0542-z10.1038/s41591-019-0542-z ↗
55. 10.1016/j.carbpol.2021.11823110.1016/j.carbpol.2021.118231 ↗
56. 10.3390/ijms1907202510.3390/ijms19072025 ↗
57. 10.1016/j.nantod.2021.10123410.1016/j.nantod.2021.101234 ↗
58. 10.1038/s41467-021-26221-y10.1038/s41467-021-26221-y ↗
59. 10.1021/acs.biomac.6b0064210.1021/acs.biomac.6b00642 ↗
60. 10.1016/j.carbpol.2020.11689210.1016/j.carbpol.2020.116892 ↗
61. 10.1002/smll.20200060110.1002/smll.202000601 ↗