DataVXACS NanoPaper
journal article·2022-08-23

Chiral FA Conjugated CdTe/CdS Quantum Dots for Selective Cancer Ablation

Guangmin Li, Xihao Zhang, Xuening Fei, Jiafeng Li, Hongfei Liu, Wei Liu, Yang Yang, Bingjing Li, Mingrui Liu, Gaoling Yang, Ti Zhang

ACS Nano· Volume 16· Issue 8
Publisher page
Source abstract

Abstract

Inducing apoptosis in cancer cells is considered a potential therapeutic mechanism underlying cancers. Here, chiral folic acid (FA) conjugated Cys-CdTe/CdS quantum dots (QDs) conjugated with a cancer-targeting ligand were fabricated to induce apoptosis in vivo. Ligand-induced chirality mechanism for FA-Cys-CdTe/CdS QDs was discussed, which is verified by density functional theory (DFT) simulation. Interestingly, we found that the circular dichroism (CD) signals of chiral QDs can effectively distinguish breast cancer cells from normal cells, where a sharp decrease in CD signal and absorption intensity can be seen. Notably, chiral FA-Cys-CdTe/CdS QDs showed significant apoptosis-inducing ability after the release of mitochondrial apoptotic factors. Furthermore, in vivo experiments showed that chiral FA-Cys-CdTe/CdS QDs provide an efficient cancer ablation through the apoptosis process with negligible toxicity, demonstrating their great potential utility in targeted anticancer agent for future clinic application.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Nanocluster Synthesis and Applications · Molecular Sensors and Ion Detection

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Science, Tianjin Chengjian University, Tianjin JinJing Road, 26, Xiqing District, Tianjin 300384, P. R. China

Department of Hepatobiliary Surgery, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute & Hospital, Binshui Road, 45, Hexi District, Tianjin 300060, P. R. China

Department Anaesthesia, Tianjin Medical University Cancer Institute & Hospital, Binshui Road, 45, Hexi District, Tianjin 300060, P. R. China

Zhongqi Zhongxin (Tianjin) Industrial Design Co., Ltd., Huixue Road 1, Xiqing District, Tianjin 300382, P. R. China

School of Optics and Photonics, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Beijing 100081, P. R. China

Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, DongAn Road 270, Xuhui District, Shanghai 200032, P. R. China

Funding

Natural Science Foundation of Beijing Municipality · Tianjin Science and Technology Committee · National Natural Science Foundation of China · National Science and Technology Major Project · Tianjin excellent science and Technology Commissioner project · Tianjin High School Science and Technology Fund Planning Project · Tianjing's Higher Education Fund for Technology and Development

References (62)

Show source-provided references
1. 10.1038/352114a010.1038/352114a0 ↗
2. 10.1038/258383a010.1038/258383a0 ↗
3. 10.1021/acs.chemrev.6b0075510.1021/acs.chemrev.6b00755 ↗
4. 10.1021/jacs.7b0144510.1021/jacs.7b01445 ↗
5. 10.1038/s41586-021-04243-210.1038/s41586-021-04243-2 ↗
6. 10.1016/j.mattod.2020.10.00710.1016/j.mattod.2020.10.007 ↗
7. 10.1002/adfm.20180237210.1002/adfm.201802372 ↗
8. 10.1002/adfm.20180551210.1002/adfm.201805512 ↗
9. 10.1021/jacs.9b0572410.1021/jacs.9b05724 ↗
10. 10.1002/anie.20191061510.1002/anie.201910615 ↗
11. 10.1002/adma.20110253810.1002/adma.201102538 ↗
12. 10.1002/ange.20190267310.1002/ange.201902673 ↗
13. 10.1002/anie.20171245310.1002/anie.201712453 ↗
14. 10.1002/anie.20200202810.1002/anie.202002028 ↗
15. 10.1021/jacs.9b0936010.1021/jacs.9b09360 ↗
16. 10.1021/jacs.1c0791510.1021/jacs.1c07915 ↗
17. 10.1021/acsnano.9b0344410.1021/acsnano.9b03444 ↗
18. 10.1038/s41467-018-06946-z10.1038/s41467-018-06946-z ↗
19. 10.1002/adma.20190387810.1002/adma.201903878 ↗
20. 10.1002/adma.20210935410.1002/adma.202109354 ↗
21. 10.1186/s12951-021-00965-710.1186/s12951-021-00965-7 ↗
22. 10.1038/bjc.1972.3310.1038/bjc.1972.33 ↗
23. 10.1126/science.278753010.1126/science.2787530 ↗
24. 10.1038/7504510.1038/75045 ↗
25. 10.1126/science.108250410.1126/science.1082504 ↗
26. 10.1021/acsnano.6b0383510.1021/acsnano.6b03835 ↗
27. 10.1021/acsnano.1c0124810.1021/acsnano.1c01248 ↗
28. 10.1021/acsnano.1c0677710.1021/acsnano.1c06777 ↗
29. 10.1002/cnma.20160025810.1002/cnma.201600258 ↗
30. 10.1021/acsami.8b1561810.1021/acsami.8b15618 ↗
31. 10.1002/adfm.20180201210.1002/adfm.201802012 ↗
32. 10.1021/acs.nanolett.6b0314310.1021/acs.nanolett.6b03143 ↗
33. 10.1021/acs.jpclett.1c0155410.1021/acs.jpclett.1c01554 ↗
34. 10.1021/jacs.9b0597310.1021/jacs.9b05973 ↗
35. 10.1038/s41467-018-07837-z10.1038/s41467-018-07837-z ↗
36. 10.1063/1.500115110.1063/1.5001151 ↗
37. 10.1021/acsnano.8b0011210.1021/acsnano.8b00112 ↗
38. 10.1039/C8NR10506E10.1039/C8NR10506E ↗
39. 10.1038/s41557-018-0083-y10.1038/s41557-018-0083-y ↗
40. 10.1002/anie.20100820610.1002/anie.201008206 ↗
41. 10.1021/ja512735210.1021/ja5127352 ↗
42. 10.1039/b405516k10.1039/b405516k ↗
43. 10.1021/acsnano.9b0910110.1021/acsnano.9b09101 ↗
44. 10.1021/ja906894r10.1021/ja906894r ↗
45. 10.1021/jacs.7b0422410.1021/jacs.7b04224 ↗
46. 10.1080/0038701060077911210.1080/00387010600779112 ↗
47. 10.1063/1.45845210.1063/1.458452 ↗
48. 10.1103/PhysRevLett.77.386510.1103/PhysRevLett.77.3865 ↗
49. 10.1103/PhysRevLett.102.07300510.1103/PhysRevLett.102.073005 ↗
50. 10.1080/0892702060058968410.1080/08927020600589684 ↗
51. 10.1021/jo00911a03410.1021/jo00911a034 ↗
52. 10.1007/s11307-010-0305-110.1007/s11307-010-0305-1 ↗
53. 10.1002/(SICI)1097-0215(19980417)79:2<121::AID-IJC4>3.0.CO;2-V10.1002/(SICI)1097-0215(19980417)79:2<121::AID-IJC4>3.0.CO;2-V ↗
54. 10.1016/j.addr.2004.01.00610.1016/j.addr.2004.01.006 ↗
55. 10.1021/jm100509v10.1021/jm100509v ↗
56. 10.1038/nnano.2012.20710.1038/nnano.2012.207 ↗
57. 10.1021/acsnano.7b0020010.1021/acsnano.7b00200 ↗
58. 10.1002/chir.2004910.1002/chir.20049 ↗
59. 10.1038/nchembio.171210.1038/nchembio.1712 ↗
60. 10.1038/nrd.2018.17410.1038/nrd.2018.174 ↗
61. 10.1038/nrc336510.1038/nrc3365 ↗
62. 10.1002/EXP.2022008210.1002/EXP.20220082 ↗