DataVXACS NanoPaper
journal article·2023-12-12Open access

Molybdenum Nanodots for Acute Lung Injury Therapy

Jiayang Yan, Zhongmin Tang, Yanan Li, Han Wang, Jessica C. Hsu, Mengmeng Shi, Zi Fu, Xiuru Ji, Weibo Cai, Dalong Ni, Jieming Qu

ACS Nano· Volume 17· Issue 23
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Source abstract

Abstract

Acute respiratory disease syndrome (ARDS) is a common critical disease with high morbidity and mortality rates, yet specific and effective treatments for it are currently lacking. ARDS was especially apparent and rampant during the COVID-19 pandemic. Excess reactive oxygen species (ROS) production and an uncontrolled inflammatory response play a critical role in the disease progression of ARDS. Herein, we developed molybdenum nanodots (MNDs) as a functional nanomaterial with ultrasmall size, good biocompatibility, and excellent ROS scavenging ability for the treatment of acute lung injury (ALI). MNDs, which were administered intratracheally, significantly ameliorated lung oxidative stress, inflammatory response, protein permeability, and histological severity in ALI mice without inducing any safety issues. Importantly, transcriptomics analysis indicated that MNDs protected lung tissues by inhibiting the activation of the Nod-like receptor protein 3 (NLRP3)-dependent pyroptotic pathway. This work presents a promising therapeutic agent for patients suffering from ARDS.
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Research context

NanomaterialsBiomaterials

OpenAlex topics: Extracellular vesicles in disease · Pneumocystis jirovecii pneumonia detection and treatment · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai 200025, China

Departments of Radiology and Medical Physics, University of Wisconsin, Madison, Wisconsin 53705, United States

Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Funding

Shanghai Jiao Tong University · National Cancer Institute · Innovative Research Team of High-level Local University in Shanghai · National Natural Science Foundation of China · University of Wisconsin-Madison · Foundation of National Facility for Translational Medicine · Shanghai Major Infectious Disease Research Base

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