DataVXACS Applied Nano MaterialsPaper
journal article·2025-06-20

Glutathione-Depleting and Reactive Oxygen Species-Amplifying Upconversion Nanoplatform for Synergistic Ferroptosis

Fangfang Ke, Shuyu Liu, Xiaoyu Ji, Nipeng Chen, Kaimin Zhang, Weijia Huang, Yilin Liu, Yongming Chen, Pengpeng Lei, Zhen Zhang, Du Cheng

ACS Applied Nano Materials· Volume 8· Issue 24
Publisher page
Source abstract

Abstract

The overexpression of glutathione (GSH) in tumor cells neutralizes reactive oxygen species (ROS), thereby limiting oxidative stress-induced cell death. In this study, we develop a tumor-responsive upconversion nanoparticle (UCNPs)-based nanoplatform, UCNPs@mMnO 2 –Hypricin (UM-H), designed to deplete intracellular GSH and potentiate ROS-mediated antitumor therapy. The MnO 2 shell selectively degrades in the presence of GSH, releasing Mn 2+ ions, restoring UCNP luminescence, and serving as an indicator of GSH depletion. The released Mn 2+ forms complexes with hypericin, enhancing ROS generation. Furthermore, Mn 2+ catalyzes the Fenton reaction, generating hydroxyl radicals (·OH) to amplify oxidative damage, resulting in significant tumor suppression with minimal toxicity.
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Research context

NanomaterialsCatalysis & surfaces

OpenAlex topics: Nanoplatforms for cancer theranostics · Extracellular vesicles in disease · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

PCFM Lab, Guangdong Engineering Technology Research Centre for Functional Biomaterials, School of Materials Science and Engineering

Sun Yat-sen University

State Key Laboratory of Molecular Engineering of Polymers

Fudan University

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China

State Key Laboratory of Antiviral Drugs, College of Chemistry and Molecular Science

Henan University

Funding

Ministry of Science and Technology of the People's Republic of China · Jilin Provincial Scientific and Technological Development Program · National Natural Science Foundation of China · State Key Laboratory of Molecular Engineering of Polymers · 2023 Guangdong Key Scientific Research Platform and Projects for the Higher-Educational Institution

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