Decoding α ‐MoC _{1− x} Nanoparticle Formation in Continuous Flow via Machine Learning

ABSTRACT Molybdenum carbide nanoparticles ( α ‐MoC _{1− x} NPs) are promising catalysts that offer noble‐metal‐like performance at lower cost. We report a mild continuous‐flow synthesis of α ‐MoC _{1− x} NPs from Mo(CO) ₆ , coupled with in‐line spectroscopic monitoring and machine learning (ML)‐based analysis to quantify precursor conversion and product formation in real time. A multilayer perceptron ML model was found to accurately deconvolute complex, nonlinear spectral patterns, enabling identification of a two‐step reaction pathway, involving precursor conversion to an amorphous intermediate followed by intraparticle crystallization to α ‐MoC _{1− x} NPs, with the first step being rate limiting. Ex situ small angle X‐ray scattering (SAXS) and X‐ray diffraction (XRD) validation confirm the predicted concentration profiles and crystallization behavior. This integrated approach showcases how ML can empower insights into NP nucleation and growth, paving the way for self‐driving, flow‐based platforms for NP synthesis.