Modular Molecular Design and Self‐Assembled Nanostructures of Saccharide‑Appended Cyclic Dipeptides for Glycosidase‑Responsive Supramolecular Hydrogels
Source abstract
Abstract
ABSTRACT Glycosidase‐responsive supramolecular hydrogels represent a promising class of soft materials for biomedical applications, as glycosidases play pivotal roles in various physiological processes and viral infections. In this study, saccharide‐appended cyclic dipeptides are designed as modular building blocks for the construction of supramolecular hydrogel systems through aqueous self‐assembly. Notably, β‐galactosidase‐responsive gel‐to‐sol and neuraminidase (sialidase)‐responsive sol‐to‐gel transitions are achieved by employing cyclic dipeptides appended with galactose and N ‐acetylneuraminic acid, respectively, under appropriate formulations.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Supramolecular Self-Assembly in Materials · Hydrogels: synthesis, properties, applications · Polydiacetylene-based materials and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
United Graduate School of Drug Discovery and Medical Information Sciences Gifu University Gifu Japan
Department of Life Science and Chemistry Graduate School of Natural Science and Technology Gifu University Gifu Japan
Institute For Advanced Study Gifu University Gifu Japan
Center For One Medicine Innovative Translational Research (COMIT) Institute For Advanced Study Gifu University Gifu Japan
Institute For Glyco‐core Research (iGCORE) Gifu University Gifu Japan
Division of Advanced Bioimaging National Cancer Center Research Institute (NCCRI) Tokyo Japan
Innovation Research Centre for Quantum Medicine Graduate School of Medicine Gifu University Gifu Japan
Funding
Japan Society for the Promotion of Science
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