DataVXSmallPaper
journal article·2026-06

Breathable, Stretchable Electroporation Patches for Drug Delivery

Zhuoran Li, Haitao Guo, Zanxin Zhou, Xinkai Xu, Guosheng Wang, Jie Cheng, Wenjun Li, Luying Zhao, Xueren Wang, Jian Li, Xuecheng Ping, Shuang Li, Qi Gu, Yewang Su

Small· Volume 22· Issue 35
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Source abstract

Abstract

ABSTRACT Arthritis has become a widespread global health issue with the aging population. Wearable transdermal drug delivery offers a promising treatment with high bioavailability and sustained drug concentrations. However, current technologies struggle with issues such as high cost, low comfort, risk of infection, or tissue pain and damage. Here, we present a breathable, stretchable electroporation patch (BSEP) that seamlessly integrates the traditional drug patch with electroporation‐enhanced transdermal drug delivery technology in a low‐cost manner. Conductive ink was patterned and deposited onto a breathable and stretchable non‐woven fabric substrate using screen printing. A unique serpentine interdigitated design for stretchable electrodes was adopted to precisely localize the electric field within the superficial layers of the skin, reducing voltage in deep tissues by >50% and minimizing potential damage. Cytotoxicity tests and histological analyses confirmed the biocompatibility and safety of the materials and device. Finally, animal experiments validated the effectiveness of the BSEP in enhancing drug delivery, achieving a two–threefold increase in skin penetration compared to the control group. These findings collectively suggest that the developed BSEP holds significant promise for transdermal drug delivery applications.
Source: crossref · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Microbial Inactivation Methods · Advancements in Transdermal Drug Delivery · Planarian Biology and Electrostimulation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences Beijing China

College of Mechanical Engineering Tianjin University of Science and Technology Tianjin China

Human Organ Physiopathology Emulation System Institute of Zoology Chinese Academy of Sciences Beijing China

State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology Beijing China

Beijing Institute for Stem Cell and Regenerative Medicine Beijing China

University of Chinese Academy of Sciences Beijing China

School of Engineering Science University of Chinese Academy of Sciences Beijing China

Henan Key Laboratory of Medical Polymer Materials Technology and Application Tuoren Medical Device Research & Development Institute Co., Ltd. Tuoren Health Technology Industrial Park Changyuan County Henan China

Zhijian Laboratory Rocket Force University of Engineering Xi'an China

School of Astronautics Northwestern Polytechnical University Xi'an China

PLA Rocket Force University of Engineering Xi'an China

Institute of Biomechanics and Medical Engineering Applied Mechanics Laboratory Department of Engineering Mechanics Tsinghua University Beijing China

Zhongke Technology Achievement Transfer and Transformation Center of Henan Province Zhengzhou Henan China

Funding

Beijing Nova Program

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