Boron‐Doped AIE Nanomaterials With NIR‐II Emission for FL/MR Dual‐Modality Tumor Imaging

ABSTRACT Boron‐doped aggregation‐induced emission (AIE) nanomaterials (B@AIE NPs) were successfully synthesized via a facile one‐pot solvothermal method for dual‐modality fluorescence (FL) and magnetic resonance (MR) imaging. The as‐prepared B@AIE NPs exhibited a uniform core–shell structure, excellent dispersibility, and strong NIR‐II fluorescence emission at 984 nm upon aggregation, attributed to restricted intramolecular motion. Moreover, the boron doping conferred remarkable T ₁ ‐weighted MR contrast capability, with a high longitudinal relaxivity (r ₁ ) of 6.12 m m ^{− 1} s ^{− 1} . In vitro studies demonstrated excellent biocompatibility and efficient cellular uptake, with preferential localization in lysosomes. In vivo experiments in HeLa tumor‐bearing mice revealed effective tumor accumulation via the enhanced permeability and retention (EPR) effect, enabling high‐contrast NIR‐II fluorescence and MR imaging. These results highlight the great potential of B@AIE NPs as a promising metal‐free nanoprobe for precise tumor diagnosis through FL/MR dual‐modal imaging.