journal article·2026-04

Multimodal Analysis of the Early Stage of Amyloid Formation via Graphene Liquid Cell Electron Microscopy (Small 21/2026)

Jungjae Park, Namgyu Noh, Ji Su Park, Sanghyeon Ji, Kunmo Koo, Junpyo Hur, Jae Deok Kim, Sung Kang, Yonghee Lee, Kyeong Min Song, Yeon Sik Jung, Yoon Huh, Jong Min Yuk

Small· Volume 22· Issue 21
Publisher page

Abstract

Amyloid Formation In the Research Article (e06612), Jong Min Yuk and co-workers illustrate the early-stage dynamics of amyloid-β oligomer formation in a liquid-flowing graphene liquid cell. Transient assemblies undergo rapid association–dissociation while maintaining a quasi-equilibrium population. A multimodal framework integrating semi-ensemble population analysis with time-sequential single-particle tracking reveals dynamic aggregation pathways beyond conventional ensemble-averaged approaches.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Alzheimer's disease research and treatments · Lipid Membrane Structure and Behavior · Topological and Geometric Data Analysis

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Affiliations

Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea

Analysis and Assessment Research Center Research Institute of Industrial Science and Technology (RIST) Pohang Republic of Korea

Department of Nano & Advanced Materials Science and Engineering Kyungpook National University (KNU) Sangju Republic of Korea

Energy Storage Material Center Korea Institute of Ceramic Engineering and Technology (KICET) Jinju Republic of Korea

GIST InnoCORE AI‐Nano Convergence Initiative for Early Detection of Neurodegenerative Diseases Gwangju Institute of Science and Technology (GIST) Gwangju Republic of Korea

References

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