Biodegradable Multispinous Magnetic Silica Nanoparticles for MRI Guided Cancer Therapy

ABSTRACT Magnetic mesoporous nanoparticles (MMNs) have garnered significant attention in cancer theranostics for their high specific surface area, large pore volume, and magnetic resonance imaging (MRI) capabilities. However, conventional MMNs primarily function as drug carriers, which often leads to drug resistance and off‐target effects. To address these limitations, we developed biodegradable magnetic spike silica nanoparticles (MSSNs) with Fe ₃ O ₄ cores and urchin‐like silica shells. Unlike conventional chemotherapy, MSSNs induce cancer cell apoptosis through their intrinsic nanomechanical action. Upon reaching the tumor microenvironment, the silica spikes on MSSNs interact with cell membranes and organelles, triggering reactive oxygen species (ROS) generation and subsequently inducing cancer cell apoptosis. Notably, this cytotoxicity is spike‐length‐dependent, with longer spikes exhibiting enhanced therapeutic efficacy. Furthermore, the superparamagnetic core enables real‐time MRI monitoring of treatment progress. In vivo experiments demonstrated significant tumor growth inhibition with no evident toxicity in major organs, highlighting the potential of MSSNs as a promising drug‐free platform for precise breast cancer therapy. This study presents a novel strategy combining nanomechanical disruption with MRI guidance, opening new avenues for multifunctional nanomaterial design in oncology.