journal article·2026-04

Polymer‐Based Prism‐Free Nanograting SPR Imaging Enables Multiplexed Detection and Single‐Step Aptamer Binding Kinetics (Small 20/2026)

Deng‐Kai Yang, Tzu‐Tsai Chu, Shu‐Cheng Lo, Yi‐De He, Jui‐Hong Weng, Liang‐Kun Yu, Kuang‐Li Lee, Pierre‐François Calmon, Pei‐Kuen Wei, Thierry Leïchlé, Chia‐Fu Chou

Small· Volume 22· Issue 20
Publisher page

Abstract

Surface Plasmon Resonance Imaging In the Research Article (e12092), Chia-Fu Chou and co-workers present a prism-free, low-cost, single-use polymer-based nanograting surface plasmon resonance imaging (SPRi) platform using normal-incidence optics and camera-based detection. Integrated with a custom microarrayer, the platform demonstrates multiplexed analysis capability. Furthermore, the incorporation of microfluidics enables simultaneous, multi-concentration kinetic analysis in a single step. This approach offers high-throughput potential for biomedical applications.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Advanced Biosensing Techniques and Applications · Gold and Silver Nanoparticles Synthesis and Applications · Biosensors and Analytical Detection

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Affiliations

Institute of Physics Academia Sinica Taipei Taiwan

Research Center of Applied Sciences Academia Sinica Taipei Taiwan

Department of Electrical Engineering National Chi Nan University Nantou County Taiwan

LAAS‐CNRS & Université de Toulouse Toulouse France

Georgia Tech‐CNRS International Research Laboratory Atlanta Georgia USA

References

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