Large‐Scale Distribution of Physical Data Using DNA‐of‐Things Technology in Newspaper Printing

ABSTRACT DNA represents a promising solution for high‐density and long‐term data storage. In this study, we explore the scalability and robustness of DNA‐of‐Things (DoT) technology by embedding digital data encoded in silica‐encapsulated DNA in newspaper ink. In honor of the 75th anniversary of the German Basic Law the “Grundgesetz” was encoded in DNA, encapsulated in silica nanoparticles, and mixed with paraffin‐based offset ink for mass distribution in a newspaper with a circulation of over 500 000 copies of “The Süddeutsche Zeitung.” We assessed the integrity and recoverability of the DNA after printing by retrieving, sequencing, and decoding the embedded data. Our results demonstrate the sensitivity and scalability of DNA‐of‐things technology. As a proof of concept, the DNA was reliably stored in printed media and successfully retrieved from a single dot of ink containing approximately 14 femtograms of DNA.