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journal article·2026-05

H‐Aggregated Squaraine Probe NIR‐II/MRI Double Reversal Imaging for Liver Cancer Precise Surgical Navigation

Ruihu Song, Yu Zhang, Zewei Zhang, Yanlin Wang, Xinning Sun, Lingling Liu, XinXing Li, De‐an Guo, Hao Chen

Small· Volume 22· Issue 28
Publisher page
Source abstract

Abstract

ABSTRACT Accurate delineation of tumor boundaries is critical for the complete resection of early‐stage liver cancer but remains a challenge for single‐modality imaging. Here, we present SQ 905‐Gd, a small‐molecule squaraine‐based dual‐modality probe designed for NIR‐II and MRI imaging to address this need. This probe uniquely leverages an aggregation‐caused quenching (ACQ) effect and intrinsic liver‐targeting properties to enable a double‐reversal imaging strategy. Preoperatively, SQ 905‐Gd enhances T 1 ‐weighted MRI, brightening liver tumors. Intraoperatively, the same aggregates quench NIR‐II fluorescence, darkening tumors against normal tissue and allowing clear visualization of sub‑2 mm lesions. Additionally, fluorescence can be restored ex vivo by solvent extraction, enabling real‐time confirmation of complete resection. To our knowledge, this is the first small‐molecule dual‐modal probe that utilizes in vivo ACQ to achieve bright/dark reversible contrast across both MRI and NIR‐II imaging, offering a powerful tool for precise liver cancer surgery.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Hepatocellular Carcinoma Treatment and Prognosis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Chemical Biology Molecular Imaging Center Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China

University of Chinese Academy of Sciences Beijing China

Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Research Center of TCM Standardization Technology Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China

School of Chinese Materia Medica Nanjing University of Chinese Medicine Nanjing China

Zhongshan Institute For Drug Discovery Shanghai Institute of Materia Medica Chinese Academy of Sciences Zhongshan China

Shanghai University of Traditional Chinese Medicine Shanghai Academy of International Standardization for Traditional Chinese Medicine Shanghai China

Funding

National Natural Science Foundation of China · Science and Technology Commission of Shanghai Municipality · National Key Research and Development Program of China

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