DataVXSmallPaper
journal article·2026-03

NQO1‐Responsive Prodrug for in Cellulo Release of Cytochalasin B as Cancer Cell‐Targeted Migrastatic (Small 16/2026)

Mervic D. Kagho, Katharina Schmidt, Christopher Lambert, Lili Jia, Vignesh Venkatakrishnan, Luisa Mehr, Johan Bylund, Klemens Rottner, Marc Stadler, Theresia E. B. Stradal, Philipp Klahn

Small· Volume 22· Issue 16
Publisher page
Source abstract

Abstract

Migrastatic Drugs In the Research Article (2410861), Theresia E. B. Stradal, Philipp Klahn, and co-workers highlight the tumor-selective migrastatic strategy underlying the NQO1-responsive prodrug BQTML-CB. It illustrates how the cancer-associated enzyme NQO1 unmasks cytochalasin B within tumor cells, triggering disruption of the actin filament network and suppression of migration and proliferation, while sparing NQO1-deficient cells and human neutrophils, thereby reducing systemic toxicity significantly. Image design by Ella Maru Studio Inc.
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Research context

OpenAlex topics: ATP Synthase and ATPases Research · Bioactive Compounds and Antitumor Agents · Genomics, phytochemicals, and oxidative stress

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry and Molecular Biology Division of Organic and Medicinal Chemistry University of Gothenburg Natrium, Medicinaregatan 7B Gothenburg 413 90 Sweden

Department of Cell Biology Helmholtz Centre for Infection Research Inhoffenstrasse 7 38124 Braunschweig Germany

Division of Molecular Cell Biology Zoological Institute Technische Universität Braunschweig Spielmannstrasse 7 38106 Braunschweig Germany

Department of Microbial Drugs Helmholtz Centre for Infection Research Inhoffenstrasse 7 38124 Braunschweig Germany

Department of Life Sciences Chalmers University of Technology Kemivägen 4 Göteborg 41296 Sweden

Department of Oral Microbiology and Immunology Institute of Odontology Sahlgrenska Academy University of Gothenburg Medicinaregatan 12F Göteborg 413 90 Sweden

Institute for Microbiology Technische Universität Braunschweig Spielmannstraße 7 38106 Braunschweig Germany

References

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