DataVXSmallPaper
journal article·2026-03

FAST‐CRISPR: Fusogenic Association and Secured Transfection of CRISPR/Cas9 Ribonucleoproteins Using Lipid‐Silica Hybrid Nanoparticles for Therapeutic Genome Editing (Small 15/2026)

Minjong Kim, Kyunghwan Kim, Jihyun Lee, Soyoung Lee, Subin Choi, Soo Ah Park, Euihwan Jeong, Song‐Yi Choi, Hee Ho Park, Tae‐Eun Park, Taejoon Kwon, Kyungjae Myung, Jounghyun Yoo, Seung Woo Cho, Jinmyoung Joo

Small· Volume 22· Issue 15
Publisher page
Source abstract

Abstract

Therapeutic Genome Editing In article number (e11362), Jounghyun Yoo, Seung Woo Cho, Jinmyoung Joo, and co-workers introduced a FAST-CRISPR (Fusogenic Association and Secured Transfection of CRISPR/Cas9) platform engineered for rapid cytosolic delivery of CRISPR/Cas9 ribonucleoproteins. By mediating direct membrane fusion to bypass endocytic pathways, it enables rapid cytosolic delivery and nuclear transport of ribonucleoproteins. This strategy successfully triggers targeted cancer cell apoptosis, establishing a promising non-viral genome editing tool.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: CRISPR and Genetic Engineering · RNA Interference and Gene Delivery · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biological Science Ulsan National Institute of Science and Technology Ulsan Republic of Korea

Center for Genomic Integrity Institute of Basic Science Ulsan Republic of Korea

Department of Chemistry Ulsan National Institute of Science and Technology Ulsan Republic of Korea

Department of Biomedical Engineering Ulsan National Institute of Science and Technology Ulsan Republic of Korea

In Vivo Research Center UNIST Central Research Facilities Ulsan National Institute of Science and Technology Ulsan Republic of Korea

Division of Research and Development CasCure Therapeutics Seoul Republic of Korea

Department of Pathology at Chungnam National University College of Medicine Daejeon Republic of Korea

Department of Biotechnology Korea University Seoul Republic of Korea

Graduate School of Health Science and Technology Ulsan National Institute of Science and Technology Ulsan Republic of Korea

References

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