DataVXSmallPaper
journal article·2026-04

Engineered Nanoplatform with Dual Anti‐Inflammatory and Microbiota‐Modulating Actions for Targeted Therapy in Chronic Inflammatory Bowel Disease

Yimeng Fang, Jing Zhao, Yaping Chen, Li Luo, Junying Qu, Zhou Yi, Rongbing Chen, Hanbing Wang, Xiaofei Hong, Wei Wu, Qinsi Yang, Da Sun

Small· Volume 22· Issue 21
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Source abstract

Abstract

ABSTRACT Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder characterized by oxidative stress, impaired antioxidant defense, and gut microbiota dysbiosis. Despite advances in treatment, current therapies remain limited by insufficient efficacy and systemic side effects. Here, we developed a multifunctional nanoplatform (BG/SOD@ZIF‐zc) by encapsulating superoxide dismutase (SOD) within Cu‐doped ZIF‐zc and coating it with bacterial ghosts for targeted delivery. This system preserved enzymatic activity under gastrointestinal conditions, scavenged reactive oxygen species, and optimized the relative composition of gut microbiota. In zebrafish models, BG/SOD@ZIF‐zc alleviated intestinal inflammation, restored antioxidant enzyme activity, reduced lipid peroxidation, and improved anxiety‐like behavior. These findings highlight a dual‐action strategy integrating antioxidant reinforcement and microbiota regulation, offering a promising therapeutic avenue for IBD.
Source: crossref · Quality: baseline

Research context

NanomaterialsComposites

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Neutrophil, Myeloperoxidase and Oxidative Mechanisms

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou University Wenzhou P. R. China

Oujiang Laboratory (Zhejiang Lab For Regenerative Medicine, Vision and Brain Health) Wenzhou P. R. China

Department of Gastroenterology the Affiliated Yiwu Hospital of Wenzhou Medical University Yiwu Central Hospital Yiwu P. R. China

Department of Biomedical Engineering City University of Hong Kong Hong Kong P. R. China

Department of Biotechnology The University of Hong Kong Hong Kong P. R. China

Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory For Vascular Implants Bioengineering College of Chongqing University Chongqing P. R. China

Wenzhou Institute University of Chinese Academy of Sciences Wenzhou P. R. China

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