Geometrically Well‐Controlled Wireframe RNA Nanostructures With Bundled‐Helix Edges
Source abstract
Abstract
ABSTRACT Wireframe RNA nanostructures with defined geometry are desirable, but bendable RNA edges can lead to structural deformation. Here, we present our design of single‐stranded RNA Origami with bundled duplexes as edges. With dual duplex bundles as the wireframe edges, a specific geometry results for our RNA constructs. We construct a number of complex RNA polygons and grids with high yield and quality. Our approach can further expand the RNA design possibilities and enable downstream biomedical applications.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · Nanopore and Nanochannel Transport Studies · RNA and protein synthesis mechanisms
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Life Sciences Tsinghua University Beijing China
Center For Synthetic and Systems Biology Tsinghua University Beijing China
Department of Chemistry Purdue University West Lafayette Indiana USA
Funding
National Key Research and Development Program of China
References (40)
Show source-provided references
1. 10.1038/natrevmats.2017.6810.1038/natrevmats.2017.68 ↗
2. 10.1038/nature0458610.1038/nature04586 ↗
3. 10.1038/nature0827410.1038/nature08274 ↗
4. 10.1038/nature2464810.1038/nature24648 ↗
5. 10.3389/fchem.2023.112617710.3389/fchem.2023.1126177 ↗
6. 10.1038/nature0230710.1038/nature02307 ↗
7. 10.1126/science.125392010.1126/science.1253920 ↗
8. 10.1126/science.aao264810.1126/science.aao2648 ↗
9. 10.1021/ar500076k10.1021/ar500076k ↗
10. 10.1126/science.110468610.1126/science.1104686 ↗
11. 10.1038/nchem.73310.1038/nchem.733 ↗
12. 10.1093/nar/gkx22710.1093/nar/gkx227 ↗
13. 10.1038/s41467‐023‐36156‐110.1038/s41467‐023‐36156‐1 ↗
14. 10.1186/s12951‐024‐02489‐210.1186/s12951‐024‐02489‐2 ↗
15. 10.1038/s41467‐017‐02435‐x10.1038/s41467‐017‐02435‐x ↗
16. 10.1038/s41467‐018‐04652‐410.1038/s41467‐018‐04652‐4 ↗
17. 10.1038/s41557‐019‐0406‐710.1038/s41557‐019‐0406‐7 ↗
18. 10.1021/acsnano.6b0573710.1021/acsnano.6b05737 ↗
19. 10.1016/j.cbpa.2024.10247910.1016/j.cbpa.2024.102479 ↗
20. 10.1080/15476286.2023.223771910.1080/15476286.2023.2237719 ↗
21. 10.1038/nnano.2015.16210.1038/nnano.2015.162 ↗
22. 10.1038/nature1458610.1038/nature14586 ↗
23. 10.1126/science.aaf438810.1126/science.aaf4388 ↗
24. 10.1021/acsnano.2c0603510.1021/acsnano.2c06035 ↗
25. 10.1016/j.chempr.2024.04.02310.1016/j.chempr.2024.04.023 ↗
26. 10.1021/ja207976q10.1021/ja207976q ↗
27. 10.1038/s41467‐019‐13457‐y10.1038/s41467‐019‐13457‐y ↗
28. 10.1038/s41467‐018‐07039‐710.1038/s41467‐018‐07039‐7 ↗
29. 10.1002/anie.20211248710.1002/anie.202112487 ↗
30. 10.1038/nsb72710.1038/nsb727 ↗
31. 10.1016/s1074‐5521(03)00146‐710.1016/s1074‐5521(03)00146‐7 ↗
32. 10.1038/s41467‐019‐08647‐710.1038/s41467‐019‐08647‐7 ↗
33. 10.1073/pnas.080384110510.1073/pnas.0803841105 ↗
34. 10.1038/s41467‐025‐59844‐610.1038/s41467‐025‐59844‐6 ↗
35. 10.1038/nature0659710.1038/nature06597 ↗
36. 10.1038/nature2465110.1038/nature24651 ↗
37. 10.1038/s41467‐025‐58938‐510.1038/s41467‐025‐58938‐5 ↗
38. 10.1021/nl050084f10.1021/nl050084f ↗
39. 10.1002/jcc.2159610.1002/jcc.21596 ↗
40. 10.1093/nar/gkg59510.1093/nar/gkg595 ↗