Precision mRNA Delivery via Ultrasound‐Controlled Release Perfluorocarbon Emulsions: An Innovative Ultrasound Theranostic Strategy with ¹⁹ F MRI Feasibility (Small 11/2026)

Haikun Liu; Mark Louis P. Vidallon; Yuyang Song; Aidan P. G. Walsh; Henry Gordon; Shulei Ren; Pengkai Shi; Bangyan Xu; Mitchell J. Moon; Sylvain Trépout; Rico F. Tabor; Alexis I. Bishop; Ulrich Flögel; Karlheinz Peter; Xiaowei Wang

doi:10.1002/smll.72781

journal article·2026-02Open access

Precision mRNA Delivery via Ultrasound‐Controlled Release Perfluorocarbon Emulsions: An Innovative Ultrasound Theranostic Strategy with ¹⁹ F MRI Feasibility (Small 11/2026)

Haikun Liu, Mark Louis P. Vidallon, Yuyang Song, Aidan P. G. Walsh, Henry Gordon, Shulei Ren, Pengkai Shi, Bangyan Xu, Mitchell J. Moon, Sylvain Trépout, Rico F. Tabor, Alexis I. Bishop, Ulrich Flögel, Karlheinz Peter, Xiaowei Wang

Small· Volume 22· Issue 11

Publisher page Open full text

Source abstract

Abstract

Ultrasound-Responsive mRNA Nanocarriers In article number e6806, Mark Louis P. Vidallon, Xiaowei Wang, and co-workers introduce nanodroplets for ultrasound-guided mRNA delivery. Trackable by ultrasound and fluorine-19 magnetic resonance imaging, the nanodroplets transform into microbubbles upon acoustic activation, enabling real-time imaging and localized mRNA delivery to vascular cells with precise spatiotemporal control.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Ultrasound and Hyperthermia Applications · Ultrasound and Cavitation Phenomena · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Molecular Imaging and NanoTherapeutics Laboratory Baker Heart and Diabetes Institute 75 Commercial Road Melbourne VIC 3004 Australia

Centre for Cardiometabolic mRNA Therapy Baker Heart and Diabetes Institute 75 Commercial Road Melbourne VIC 3004 Australia

Department of Cardiometabolic Health University of Melbourne Parkville VIC 3010 Australia

School of Chemistry Monash University Clayton VIC 3800 Australia

Baker Department of Cardiovascular Research Translation and Implementation La Trobe University Bundoora VIC 3086 Australia

Atherothrombosis and Vascular Biology Laboratory Baker Heart and Diabetes Institute 75 Commercial Road Melbourne VIC 3004 Australia

Ramaciotti Centre for Cryo‐electron Microscopy Monash University Clayton VIC 3800 Australia

School of Physics and Astronomy Monash University Clayton VIC 3800 Australia

Institute for Molecular Cardiology Medical Faculty and University Hospital Düsseldorf Heinrich‐Heine‐University Düsseldorf Universitätsstraße 1 40225 Düsseldorf Germany

Cardiovascular Research Institute Düsseldorf (CARID) Medical Faculty and University Hospital Düsseldorf Heinrich‐Heine University Düsseldorf Universitätsstraße 1 40225 Düsseldorf Germany

School of Translational Medicine Monash University Melbourne VIC 3004 Australia

References

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