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journal article·2026-01Open access

Corneal Nerve Regeneration via MSC‐Derived EVs: Tissue Source and Culture Dimensionality Dictate miRNA Cargo and Therapeutic Efficacy (Small 6/2026)

Hamed Massoumi, Eitan A. Katz, Melinda Alviar, Qiang Zhou, Mauricio Gonzalez Oyarzun, Deepshikha Tewari, Makayla Dove, Hanieh Niktinat, Tara Nguyen, Seyed Mahbod Baharnoori, Khandaker Anwar, Mark Maienschein Cline, Yuanxiang Li, Xiaowei Wang, Victor H. Guaiquil, Mark I. Rosenblatt, Ali R. Djalilian, Elmira Jalilian

Small· Volume 22· Issue 6
Publisher pageOpen full text
Source abstract

Abstract

Extracellular Vesicles In article number e07451, Elmira Jalilian and co-workers investigated how tissue source and culture dimensionality dictate the cargo and efficacy of extracellular vesicles (EVs). The artwork depicts EVs (gold spheres) delivering their distinct miRNA cargo to damaged neurons, facilitating neurotrophic signalling and extracellular matrix remodelling. This study highlights that 3D culture significantly enhances EV yield and regenerative potency, establishing a framework for designing precise, cell-free therapies for ocular nerve repair.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Extracellular vesicles in disease · Corneal Surgery and Treatments · interferon and immune responses

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Ophthalmology and Visual Sciences Illinois Eye and Ear Infirmary. University of Illinois Chicago Chicago IL 60612 USA

Richard and Loan Hill Department of Biomedical Engineering University of Illinois Chicago Chicago IL 60607 USA

Department of Pharmacology and Regenerative Medicine University of Illinois Chicago Chicago Illinois 606012 USA

University of Illinois Cancer Center Chicago Illinois 60612 USA

References

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