DataVXSmallPaper
journal article·2025-12Open access

Integration of Generative Protein Design with Synthetic Porphyrin Assembly: Metal‐Responsive Cyclic Assembly of a Bi‐Porphyrin Acquisition Designer Protein (Small 49/2025)

Hiroaki Inaba, Hiroki Onoda, Takayuki Uchihashi, Atsunori Oshima, Osami Shoji

Small· Volume 21· Issue 49
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Source abstract

Abstract

Protein Design Generative protein design meets synthetic porphyrin assembly to yield a metal-responsive cyclic protein assembly, highlighting the synergy of protein engineering and synthetic chemistry. By fusing α/β-folded porphyrin-binding motifs, the de novo designed protein captures two synthetic porphyrins bearing an additional metal coordination site, resulting in a metal-triggered cyclic assembly and dynamic structural transformations. More in article number 2505625, Takayuki Uchihashi, Osami Shoji, and co-workers.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Porphyrin Metabolism and Disorders · Cyclopropane Reaction Mechanisms · Supramolecular Self-Assembly in Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry School of Science Nagoya University Furo‐cho, Chikusa‐ku Nagoya Aichi 464‐0802 Japan

AICHI SR Center Nagoya University Minamiyamaguchi‐cho Nagoya Aichi 464‐8603 Japan

Exploratory Research Center on Life and Living Systems National Institutes of Natural Sciences Okazaki 444‐8787 Japan

Institute for Glyco‐core Research (iGCORE) Nagoya University Nagoya Aichi 464‐0814 Japan

Department of Physics School of Science Nagoya University Furo‐cho, Chikusa‐ku Nagoya Aichi 464‐0802 Japan

Cellular and Structural Physiology Institute (CeSPI) Nagoya University Furo‐cho, Chikusa‐ku Nagoya Aichi 464‐8601 Japan

Department of Basic Medicinal Sciences Graduate School of Pharmaceutical Sciences Nagoya University Furo‐cho, Chikusa‐ku Nagoya Aichi 464‐8601 Japan

Center for One Medicine Innovative Translational Research (COMIT) Gifu University Institute for Advanced Study Gifu 501‐11193 Japan

Research Institute for Quantum and Chemical Innovation Institutes of Innovation for Future Society Nagoya University Furo‐cho, Chikusa‐ku Nagoya 461‐8601 Japan

References

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