Bypassing Endocytic Barriers: Visualizing Membrane Fusion and Endosomal Escape of Cubic Phase Lipid Nanoparticles (Cubosomes) (Small 44/2025)

Cubic Phase Lipid Nanoparticles Cubosomes, a unique class of lipid nanoparticles, show direct membrane fusion with mammalian cells, bypassing conventional endocytic pathways. Using a combination of advanced microscopy techniques, in article number 2502231, Calum J. Drummond, Charlotte E. Conn, Nhiem Tran, and co-workers visualize cubosome interactions at the nanoscale, uncovering mechanisms of lipid exchange, membrane disruption, and endosomal escape. These findings highlight cubosomes as promising next-generation nanocarriers for efficient cytosolic delivery of therapeutics.