Functional and Structural Analyses of Diverse G‐Quadruplex and Non‐G‐Quadruplex Structures Formed by Guanine‐Rich Nucleic Acids: A Study on the Insulin Aptamer (Small 43/2025)
Source abstract
Abstract
G-Quadruplex Structures In article number 2501336, Naoya Iwano, Taiji Oyama, Kazunori Ikebukuro, and co-workers report for the first time that guanine-rich DNA can specifically bind to proteins without forming G-quadruplex structures. This study sheds light on how guanine-rich sequences can modulate binding affinity through mechanisms independent of G-quadruplex formation, highlighting a wide variety of the structures of guanine-rich DNA.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: DNA and Nucleic Acid Chemistry · RNA Interference and Gene Delivery · Synthesis and Characterization of Heterocyclic Compounds
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Affiliations
Toray Research Center, Inc. 10‐1 Tebiro 6‐chome Kamakura Kanagawa 248‐0036 Japan
Department of Biotechnology and Life Science Tokyo University of Agriculture and Technology 2‐24‐16 Naka‐cho Koganei Tokyo 184–8588 Japan
JASCO Corporation 2967‐5, Ishikawamachi Hachioji Tokyo 192–8537 Japan
Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill and North Carolina State University Chapel Hill North Carolina 27599 USA
References
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