journal article·2025-10Open access

3D‐Printed Microfluidic Platform for Creating Porous Nanofibrous Microspheres to Regulate Cell Response and Enhance Tissue Regeneration (Small 41/2025)

Donghee Lee, Huy Quang Tran, Navatha Shree Sharma, Syed Muntazir Andrabi, Zishuo Yan, Amy C. Killeen, Richard A. Reinhardt, Wuqiang Zhu, Jingwei Xie

Small· Volume 21· Issue 41

Abstract

Porous Nanofibrous Microspheres In article number 2502033, Jingwei Xie and co-workers introduce a novel 3D-printed microfluidic platform for fabricating porous nanofibrous microspheres (PNMs) with tunable size, pore architecture, and bioactive peptide functionalization. The featured SEM image highlights the porous structure of PNMs, which underpins enhanced cell infiltration, controlled release of osteogenic, angiogenic, and anti-inflammatory cues, and rapid in vivo integration, demonstrating PNMs’ potential as injectable scaffolds for tissue regeneration.
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Research context

OpenAlex topics: 3D Printing in Biomedical Research · Electrospun Nanofibers in Biomedical Applications

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Affiliations

Department of Surgery‐Transplant and Mary & Dick Holland Regenerative Medicine Program University of Nebraska Medical Center Omaha NE 68198 USA

Department of Surgical Specialties College of Dentistry University of Nebraska Medical Center Omaha NE 68198 USA

Department of Cardiovascular Medicine Physiology and Biomedical Engineering Center for Regenerative Medicine Mayo Clinic Arizona Scottsdale AZ 85259 USA

Department of Mechanical and Materials Engineering College of Engineering University of Nebraska‐Lincoln Lincoln NE 68588 USA

References

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