The Internal Nanostructure of Lipid Nanoparticles Influences Their Diverse Cellular Uptake Pathways (Small 40/2025)
Source abstract
Abstract
Lipid Nanoparticles In article number 2500903, Calum J. Drummond, Charlotte E. Conn, Nhiem Tran, and co-workers reveal that non-lamellar lyotropic liquid crystalline nanoparticles (cubosomes, hexosomes, micellar cubosomes) predominantly enter via passive fusion and macropinocytosis, bypassing endocytic recycling seen with lamellar liposomes. These findings highlight mesophase-dependent internalization and advance understanding of lipid nanoparticle–cell interactions crucial for drug delivery.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Cancer, Lipids, and Metabolism · Fatty Acid Research and Health · Metabolomics and Mass Spectrometry Studies
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Affiliations
School of Science STEM College RMIT University Melbourne Victoria 3000 Australia
Biophotonics Laboratory Immunology Frontier Research Center Osaka University Suita Osaka 5650871 Japan
References
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